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홈 > 분야별

의약학 > 종양학 (3,223건)

광대뼈에 발생한 뼈내혈관종의 증례 보고
광대뼈에 발생한 뼈내혈관종의 증례 보고
정민경(Minkyoung Jeong);권용석(Yongseok Kwon);전동근(Dongkeun Jun);이명철(Myungchul Lee);김지남(Jeenam Kim);신동혁(Donghyeok Shin);김완섭(Wan-seop Kim);최현곤(Hyungon Choi)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 33-37 (5 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Intraosseous hemangioma is a rare, benign vascular tumor of endothelial origin. It accounts for fewer than 1% of all hemangiomas, and very rarely occurs in the face. Intraosseous hemangioma usually presents as an asymptomatic lesion, but symptoms can occur due to the mass effect. The authors describe a case of intraosseous hemangioma of the zygoma with a review of the relevant literature. A 44-year-old man presented with a chief complaint of painless swelling on the left zygomatic region that had been slowly growing for the past year. On physical examination, a hard, non-movable mass in a deep layer was palpated. On computed tomography performed to evaluate its layers and extent, trabeculation was found inside the mass, but the lack of destruction of the surrounding bone suggested that the mass was benign. Complete surgical excision was performed under local anesthesia. After complete excision of the mass, slight erosions remained on the cortical bone of the zygoma, but because it was small enough not to cause a facial deformity such as depression or asymmetry, no additional reconstructive procedure was performed. There were no symptoms or recurrence during a 8-month follow-up period.
전두-안와 구역에 발생한 섬유성 이형성증의 근치적 절제술 및 자가두개골 이식을 이용한 재건을 통한 치료: 증례보고
전두-안와 구역에 발생한 섬유성 이형성증의 근치적 절제술 및 자가두개골 이식을 이용한 재건을 통한 치료: 증례보고
최지안(Ji-An Choi);곽정하(Jung-Ha Kwak);윤청민(Chung-Min Yoon)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 57-61 (5 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Fibrous dysplasia is a bone condition characterized by the replacement of normal bone tissue and the medullary cavity by abnormal fibrous tissues. Craniofacial fibrous dysplasia causes facial asymmetry compromising the aesthetics as well as vision and hearing. A 21-year-old male visited the clinic due to vertical orbital dystopia and exophthalmos that had developed over the previous 2 months. The patient was diagnosed with a fibrous dysplasia of the frontal, ethmoid bones and superior orbital wall. By a bicoronal incision on the scalp, the radical resection of the lesions was done. After harvesting the remaining frontal bone, we did the autogenous reconstruction using split calvarial bone graft. Postoperatively, the vertical orbital dystopia and exophthalmos significantly improved. The patient is satisfied with the surgical outcomes and has not reported any recurrence.
국민건강보험공단 표본코호트DB를 이용한 한국 갑상선암 발생률의 추이 변화: 10년간 분석(2004-2013)
국민건강보험공단 표본코호트DB를 이용한 한국 갑상선암 발생률의 추이 변화: 10년간 분석(2004-2013)
이진석(Jin-Seok Lee);강상욱(Sang-Wook Kang);임치영(Chi Young Lim)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 11-16 (6 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Background/Objectives: To analyze changes in the incidence of thyroid cancer for Korean population using big data from the National Health Insurance Service. Materials & Methods: Sample cohort database between January 2004 and December 2013 with 1,000,000 cases for each year was enrolled in this study. Thyroid cancer incidence was analyzed by sex, age and by region. Public health insurance payment was used to reflect socioeconomic status. Results: The incidence of thyroid cancer in Korea increased for 10 years annually. There are 3 times increasing in the incidence rate of thyroid cancer from 2004, 0.03% to 2013, 0.09%. The sex ratio in the incidence rate of thyroid cancer was male : female = 1:7.2 in 2004 and male : female = 1:3.6 in 2013 that suggest decreased gap between the sex ratio. Between 2004 and 2010, the incidence rates of those in their 40s were found to be the highest, whereas the incidence rates for those in their 50s were found to be highest from 2011 and thereafter. Every year the high socioeconomic status group showed a higher incidence of thyroid cancer than low socioeconomic status group. Some specific region showed continuous high incidence of thyroid cancer, not all city and state. Conclusion: The incidence rate of thyroid cancer for 10 years had special feature by sex, age, socioeconomic status and especially by region. This results will be a barometer for further epidemiologic study about the incidence of thyroid cancer for Korean population
악하선 절제술 후 발생한 역설적 아랫 입술 경련
악하선 절제술 후 발생한 역설적 아랫 입술 경련
유지섭(Ji Seob Yoo);홍용태(Yong Tae Hong)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 29-32 (4 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Benign submandibular gland tumor is a common disease in the head and neck region and can be completely removed by transcervical approach. Typical submandibular gland resection can lead to neurological complications. The most common complications are damage to the marginal mandibular branch of the facial nerve and weakening of the lower lip. We report a case of ipsilateral lower lip twitching occurring 3 months after surgery. There was no difficulty during the operation, and there were no neurologic complications immediate after surgery. However, in the present case, the patient experienced lower lip twitching paradoxically after surgery which has not been reported in the literature yet. Therefore, we reported this case with a review of relevant literature.
상순 구순점막에 발생한 점액낭선암종 1예
상순 구순점막에 발생한 점액낭선암종 1예
엄정환(Jung Hwan Um);조동인(Dong In Jo);김순흠(Soon Heum Kim)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 43-46 (4 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Mucinous cystadenocarcinoma (MCA) is a malignant tumor that mainly occurs in the breast or ovary, but MCA is internationally rarely reported in head and neck region. Especially MCA in minor salivary gland of oral cavity is even more rare. It is characterized by cystic spaces lining of epithelial cells containing intracytoplasmic mucin. We report a case of MCA in the labial mucosa of upper lip considered to develop from minor salivary gland with a review of literatures.
증례보고: 22세의 젊은 아시아인의 턱에서 진단된 안구외부위 피지샘암종의 진단 1례
증례보고: 22세의 젊은 아시아인의 턱에서 진단된 안구외부위 피지샘암종의 진단 1례
홍준식(Joon Shik Hong);신혜경(HeaKyeong Shin);정규용(Gyu Yong Jung);이준호(Joon Ho Lee)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 53-56 (4 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Sebaceous carcinoma (SC) is a rare malignant tumor, with an estimated incidence of approximately 1 to 2 per 1,000,000 per year. Approximately 75% of SCs are reported to occur in eyelids. Most of these tumors are diagnosed at age 40 or over and exhibit a wide variety of patterns in addition to the general appearance previously reported. SC is difficult to diagnose clinically, but can be diagnosed by accompanying biopsy. In cases of SC, additional examinations, such as endoscopy and computed tomography, may be necessary because of its association with Muir-Torre Syndrome. We present the case of a 22-year-old Asian man who complained of a rapidly growing chin tumor. The tumor was treated by surgical resection and adjuvant radiation therapy.
두경부암의 양성자치료
두경부암의 양성자치료
오동렬(Dongryul Oh)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 1-10 (10 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Intensity-modulated radiation therapy (IMRT) using X-rays is a standard technique implemented for treating head and n eck cancer (HNC). Compared to 3D conformal RT, IMRT can significantly reduce the radiation dose to surrounding normal tissues by using a highly conformal dose to the tumor. Proton therapy is a type of RT that uses positively charged particles named protons. Proton therapy has a unique energy deposit (i.e., Bragg peak) and greater biological effectiveness than that of therapy using X-rays. These inherent properties of proton therapy make the technique advantageous for HNC treatment. Recently, advanced techniques such as intensity-modulated proton therapy have further decreased the dose to normal organs with a higher conformal dose to the tumor. The usage of proton therapy for HNC is becoming widespread as the number of operational proton therapy centers has increased worldwide. This paper aims to present the current clinical evidence of proton therapy utility to HNC clinicians through a literature review. It also discusses the challenges associated with proton therapy and prospective development of the technique.
이하선에 발생한 아구양 외투세포 림프종 1예
이하선에 발생한 아구양 외투세포 림프종 1예
백문승(Moon Seung Beag);문성규(Seong Kyu Moon);이미지(Mi Ji Lee);김승우(Seung Woo Kim)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 23-27 (5 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Mantle cell lymphoma (MCL) is a rare subtype of B-cell neoplasm and it accounts for about 3~6% of all non-Hodgkin s lymphomas. It occurs mainly in middle-aged or elderly man, involving the extra-nodal sites such as gastrointestinal tract, bone marrow and Waldeyer’s ring. The incidence of the MCL in salivary gland is about 3%. The blastoid MCL is a rare variant and it has a very aggressive clinical course. It is extremely rare to be arising from the parotid gland. To our knowledge, similar case has not been reported in domestic literature, one case has been described in English literature. We experienced a rare and unique disease entity and report it with brief literature review.
이개에 발생한 신경초종 1예
이개에 발생한 신경초종 1예
서동경(Dongkyung Seo);카와시마 쿠니히로(Kunihiro Kawashima);호리우치 카츠미(Katsumi Horiuchi);요시다 테츠노리(Tetsunori Yoshida)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 39-42 (4 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Schwannomas are benign tumors of neuroectodermal origin and can be found in any part of the body. Although schwannomas are common in the head and neck region, they are rare in the auricle. Auricular schwannomas are rarely symptomatic but the mass itself or a surgical procedure to remove it may disrupt the complicated structure of the auricle. We report a rare case of auricular schwannoma with a literature review and describe the surgical technique used in this case.
갑상선 유두암종의 갑상선내 확산 1례
갑상선 유두암종의 갑상선내 확산 1례
이정규(Jung Kyu Lee);조용민(Yong Min Cho);이진환(Jin Hwan Lee);우정수(Jeong-Soo Woo);조재구(Jae-Gu Cho)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 47-51 (5 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Papillary thyroid carcinoma (PTC) typically has a good prognosis, but it frequently metastasizes to the regional lymph nodes. Although survival impact of lymph node metastasis is not clear, complementary treatment is generally added after surgery when lymphatic metastasis exists. Several previous studies have reported that the multifocal PTC is associated with poor prognosis and requires selective neck dissection to prevent regional lymph node metastasis, but they are under controversy. In this study, we present a 24-year-old female patient, diagnosed as PTC with intrathyroidal spread and regional lymph node metastases. Intrathyroidal spread of PTC can only be observed microscopically and is believed to have the similar origin of unicentric multifocal PTC. As multifocal PTC is highly associated with regional lymph node metastasis and requires an additional treatment, PTC with intrathyroidal spread may follow a similar clinical course and treatment plan. Here we report the case with a brief literature review and expect its attribution to further academic interest of treatment choice.
피부이식과 흉쇄유돌근 피판을 이용한 기관 결손의 재건 1례
피부이식과 흉쇄유돌근 피판을 이용한 기관 결손의 재건 1례
장수경(Soo Kyung Jang);서강현(Gang Hyeon Seo);최선(Sun Choi);박석현(Seok Hyun Park);김진환(Jin Hwan Kim);이동진(Dong Jin Lee)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 63-66 (4 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Supracricoid partial laryngectomy (SCPL) with cricohyoidoepiglottopexy (CHEP) or cricohyoidopexy (CHP) involves the removal of the whole thyroid cartilage, both true and false vocal cords, the ventricles, and the paraglottic spaces, sparing the cricoid cartilage, hyoid bone, and at least one functional and mobile cricoarytenoid unit. Reconstruction is performed by suturing of the cricoid cartilage up tightly to the hyoid bone, so trachea-releasing procedures are needed to prevent leakage at anastomosis site. In case of advanced tranglottic cancer invading tracheal tracheal wall, we need to perform additional circumferentrial circumferential tracheal wall resection. However, when we perform SCPL, circumferential resection of tracheal wall is limited because SCPL procedure itself needs releasing of tracheal length. We report a case of advanced transglottic cancer involving tracheal wall treated with induction chemotherapy and SCPL including tracheal wall resection with reconstruction of tracheal defect by sternocleidomastoid muscle flap covered with skin graft.
두경부암 환자에서 근치적 방사선치료 후 12주 시행한 양전자방출촬영의 임상적 중요성에 대한 연구
두경부암 환자에서 근치적 방사선치료 후 12주 시행한 양전자방출촬영의 임상적 중요성에 대한 연구
김영일(Young-il Kim);김준상(Jun-sang Kim);권진이(Jeanny Kwon);김섭(Sup Kim);서영덕(Youngduk Seo);구본석(Bon-seok Koo);장재원(Jae-won Chang);조문준(Moon-June Cho)
대한두경부종양학회 / 대한두경부종양학회지 제37권 제1호 / 2021 / 17-22 (6 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Background/Objectives: To evaluate clinical significance of FDG PET-CT for detection of residual cancer cells after curative radiation therapy or chemoradiotherapy for patients with squamous cell carcinoma (SCC) of Head and Neck Materials & Methods: A retrospective analysis of patients with SCC of Head and neck with curative radiotherapy or chemoradiotherpy between June 2011 and Jan. 2019 was performed. Sixty patients were treated with Intensity-modulated radiotherapy (IMRT). The Metabolic responses were evaluated on the post-treatment FDG PET-CT at 12 weeks after curative radiotherapy completion. Results: Median follow up was 51.5 months (3-102). The overall survival (OS), disease free survival (DFS), local control rate (LCR), and Distant metastasis free survival (DMFS) at 5 years were 80.5%, 80.1%, 87.7% and 89.1%. Metabolic CR was found in 43 (71.7%) and partial metabolic response (PR) was noted in 17 (14.6%). Metabolic CR was significantly correlated with OS, DFS, LCR, and DMFS. On multivariate analysis, Metabolic CR remained significant for DFS and LCR. Conclusion: Metabolic CR on post-radiotherapy FDG PET-CT is highly predictive of increased DFS and LCR in patients with head and neck cancer.
A randomized prospective study comparing acute toxicity, compliance and objective response rate between simultaneous integrated boost and sequential intensity-modulated radiotherapy for locally advanced head and neck cancer
A randomized prospective study comparing acute toxicity, compliance and objective response rate between simultaneous integrated boost and sequential intensity-modulated radiotherapy for locally advanced head and neck cancer
Akanksha Grover;Tej Prakash Soni;Nidhi Patni;Dinesh Kumar Singh;Naresh Jakhotia;Anil Kumar Gupta;Lalit Mohan Sharma;Shantanu Sharma;Ravindra Singh Gothwal
대한방사선종양학회 / 대한방사선종양학회지 제39권 제1호 / 2021 / 15-23 (9 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
초록보기
Purpose: Intensity-modulated radiotherapy (IMRT) provides higher dose to target volumes and limits the dose to normal tissues. IMRT may be applied using either simultaneous integrated boost (SIB-IMRT) or sequential boost (SEQ-IMRT) technique. The objectives of this study were to compare acute toxicity and objective response rates between SIB-IMRT and SEQ-IMRT in patients with locally advanced head and neck cancer. Materials and Methods: Total 110 patients with locally advanced carcinoma of oropharynx, hypopharynx, and larynx were randomized equally into the two arms (SIB-IMRT vs. SEQ-IMRT). Patients in SIB-IMRT arm received dose of 66 Gy in 30 fractions, 5 days a week, over 6 weeks. SEQ-IMRT arm’s patients received 70 Gy in 35 fractions over 7 weeks. Weekly concurrent cisplatin chemotherapy was given in both arms. Patients were assessed for acute toxicities during the treatment and for objective response at 3 months after the radiotherapy. Results: Grade 3 dysphagia was significantly more with SIB-IMRT compared to SEQ-IMRT (72% vs. 41.2%; p = 0.006) but other toxicities including mucositis, dermatitis, xerostomia, weight-loss, incidence of nasogastric tube intubation and hospitalization for supportive management were similar in both the arms. Patients in SIB-IMRT arm showed better treatment-compliance and had significantly less treatment-interruption compared to SEQ-IMRT arm (p = 0.028). Objective response rates were similar in both the arms (p = 0.783). Conclusion: Concurrent chemoradiation with SIB-IMRT for locally advanced head and neck cancer is well-tolerated and results in better treatment-compliance, similar objective response rates, comparable incidence of mucositis and higher incidence of grade 3 dysphagia compared to SEQ-IMRT.
Palliative treatment of Kaposi sarcoma with radiotherapy: a single center experience
Palliative treatment of Kaposi sarcoma with radiotherapy: a single center experience
Gonca Altinisik Inan;Ipek Pinar Aral;Suheyla Aytac Arslan;Yilmaz Tezcan
대한방사선종양학회 / 대한방사선종양학회지 제39권 제1호 / 2021 / 41-47 (7 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
초록보기
Purpose: The aim of this study is to evaluate the treatment responses of Kaposi sarcoma patients treated with radiotherapy (RT). Materials and Methods: The data of 18 patients (40 different regions) who were treated for Kaposi sarcoma in Department of the Radiation Oncology, Ankara City Hospital, Turkey between March 23, 2010 to February 13, 2018 were evaluated retrospectively. The primary endpoint of the study was the clinical-subjective response after RT, and the secondary endpoint was the visual response assessment after RT. Results: In evaluating the patients’ reported response of the lesions: 25 (62.5%) of complete response (CR), 12 (30%) of partial response (PR), and stable response was seen in 3 patients (7.5%). Patient reported response after RT was significantly higher in male sex (p = 0.002; odds ratio [OR] = 13.8, 95% confidence interval [CI], 2.7–70.0). Physician reported response rates were available for 28 lesions and CR was detected in 12 lesions (30%); PR was observed in 16 (40%). The relationship between physician reported outcome and RT techniques (electron, bolus, or water bolus) is close to the limit of statically significance (p = 0.052). Fewer lesions disappeared in patients with photon preference than electrons (p = 0.036; OR = 0.093; 95% CI, 0.009–0.950). Patients’ reported complete response rates were significantly higher in the 20 Gy per 5 fractions treatment arm (p = 0.042; OR = 1.75; 95% CI, 1.1–2.7). Conclusion: RT is an effective local treatment with high response rates in the treatment of Kaposi sarcoma. The subjective-clinical response rate was higher in male sex and the visual response was higher in the 20 Gy per 5 fractions arm. Additional studies are needed to standardize RT dose and techniques.
Clinical behaviour and outcome in pediatric glioblastoma: current scenario
Clinical behaviour and outcome in pediatric glioblastoma: current scenario
Aditya Kumar Singla;Renu Madan;Kirti Gupta;Shikha Goyal;Narendra Kumar;Sushant Kumar Sahoo;Deepak K. Uppal;Chirag K. Ahuja
대한방사선종양학회 / 대한방사선종양학회지 제39권 제1호 / 2021 / 72-77 (6 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
초록보기
Pediatric glioblastoma (pGBM) is a rare entity accounting for only approximately 3% of all childhood brain tumors. Treatment guidelines for pGBM have been extrapolated from those in adult glioblastoma. Rarity of pGBM and underrepresentation of pediatric population in major studies precludes from defining the ideal treatment protocol for these patients. Maximum safe resection is performed in most of the cases followed by postoperative radiotherapy in children over 3 years of age. Benefit of temozolomide is unclear in these patients. Here, we present the clinicopathological details and outcome of six pGBM patients treated at our institute in 2018–2019.
Atlas of sentinel lymph nodes in early breast cancer using single-photon emission computed tomography: implication for lymphatic contouring
Atlas of sentinel lymph nodes in early breast cancer using single-photon emission computed tomography: implication for lymphatic contouring
Sergey Nikolaevich Novikov;Pavel Ivanovich Krzhivitskii;Yulia Sergeevna Melnik;Alina Albertovna Valitova;Zhanna Viktorovna Bryantseva;Irina Alexandrovna Akulova;Sergey Vasilevich Kanaev
대한방사선종양학회 / 대한방사선종양학회지 제39권 제1호 / 2021 / 8-14 (7 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
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Purpose: To determine the localization of sentinel lymph nodes (SLNs) in a large cohort of patients with breast cancer and validate the European Society for Therapeutic Radiology and Oncology (ESTRO), Radiation Therapy Oncology Group (RTOG), and Radiotherapy Comparative Effectiveness (RADCOMP) guidelines on regional lymph node clinical target volume (CTV-LN) delineation. Materials and Methods: A total of 254 women with cT1-3N0-1M0 breast cancer underwent single-photon emission computed tomography (SPECT-CT) visualization of SLNs after intra- and peritumoral injection of 99mTc-radiocolloids. All SPECT-CT images were fused with reference simulation computed tomography. A 3D atlas of SLNs was created and used for evaluation of CTV-LN defined by contouring guidelines. Results: SPECT-CT visualized 532 SLNs that were localized in axillary level I in 67.5%, level II in 15.4%, level III in 7.3%, internal mammary in 8.5%, and supraclavicular in 1.3% cases. The majority of level II–IV and internal mammary SLNs were inside the recommended CTV-LN. Axillary level I SLNs were covered by ESTRO and RTOG contours in 85% and 85% cases, respectively. “Out of contours” SLNs were mostly detected in lateral subgroup of level I LN (18.5%), while 98%–99% of anterior pectoral and central axillary SLNs were covered by CTV-LN. Internal mammary SLNs were visualized in 33 cases and were outside ESTRO and RTOG contours in 3 and 6 observations, respectively. Conclusion: SPECT-CT atlas of SLNs demonstrated that in most cases ESTRO and RTOG guidelines correctly represented CTV-LNs with the exception of lateral subgroup of SLNs.
Stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of liver metastases in oligometastatic patients: initial clinical experience
Stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of liver metastases in oligometastatic patients: initial clinical experience
Gamze Ugurluer;Teuta Zoto Mustafayev;Gorkem Gungor;Banu Atalar;Ufuk Abacioglu;Meric Sengoz;Fulya Agaoglu;Gokhan Demir;Enis Ozyar
대한방사선종양학회 / 대한방사선종양학회지 제39권 제1호 / 2021 / 33-40 (8 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
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Purpose: We aimed to present our initial clinical experience on the implementation of a stereotactic M2021-04-26methods for treatment of liver metastases in oligometastatic disease with the advantages of better visualization of soft tissue, real-time tumor tracking and potentially reduced toxicity to organs at risk.
Radioprotective potential of Costus afer against the radiation-induced hematological and histopathological damage in mice
Radioprotective potential of Costus afer against the radiation-induced hematological and histopathological damage in mice
Idowu Richard Akomolafe;Naven Chetty
대한방사선종양학회 / 대한방사선종양학회지 제39권 제1호 / 2021 / 61-71 (11 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
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Purpose: This study investigated the possible radioprotective effect of Costus afer extract (CAE) on hematological and histopathological parameters of mice. Materials and Methods: Fifty-four male mice with mass between 37–43 g, 11–13 weeks old were used for this study. We divided the mice into six different groups containing nine animals, which were then further sub-divided into irradiated groups and un-irradiated groups. Animals received 250 mg/kg body weight extract of CAE by oral gavage for 6 days in addition to feeding and water ad libitum. Animals in the irradiated group were exposed to radiation at the Department of Radiotherapy and Oncology, Grey’s Hospital using a linear accelerator. Blood samples were collected at 48-hour post-irradiation for the hematology test followed by histopathology examination of kidney and liver. Results: Our findings revealed that 3 Gy and 6 Gy dose of X-ray radiation caused a significant reduction in the white blood cell, packed cell volume, hemoglobin, neutrophils, lymphocytes, eosinophils, and platelet counts compared with the control group. However, the administration of CAE before irradiation significantly increased the mentioned parameters. There was no increase in red blood cell and monocyte among treated groups compared with the control. Histopathological changes in the kidney and liver sections revealed that no visible lesion in the pretreated mice. Hepatocytes seem to be within normal histological limits. Conclusions: This study concludes that CAE offered some protection against radiation-induced hematological alterations, but there was no significant improvement in the histopathological parameters. Thus, further studies are needed to validate its radioprotective effect on histopathological variables.
Systemic therapy augmented by radiotherapy (STAR) effect for brain metastases in a BRAF-mutated melanoma patient with prolonged survival: a case report
Systemic therapy augmented by radiotherapy (STAR) effect for brain metastases in a BRAF-mutated melanoma patient with prolonged survival: a case report
Agostino Cristaudo;Antonio Malorgio;Serena Medoro;Antonio Stefanelli
대한방사선종양학회 / 대한방사선종양학회지 제39권 제1호 / 2021 / 78-81 (4 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
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Brain metastases are common in stage IV malignant melanoma, carrying a prognosis traditionally regarded as severe, with a median survival of few months. Recently introduced systemic therapies as targeted therapy or immunotherapy have significantly improved the prognosis of metastatic melanoma. The optimal association of radiotherapy to such novel treatments has to be clarified. We report on a 43-year-old woman with 10 brain metastases. Three of them were treated with stereotactic radiosurgery (SRS) with complete response even of the untreated lesions. As the patient was BRAF-mutated, she was started on dabrafenib/trametinib. After 8 months she developed new brain metastases, which again responded to a new treatment with SRS. As after 7 months additional lesions appeared, she was treated with whole brain radiotherapy and was started on nivolumab. Twenty months after the first diagnosis of brain metastases the patient is fit without significant clinical and radiological signs of toxicity.
Optimizing e-learning in oncology during the COVID-19 pandemic and beyond
Optimizing e-learning in oncology during the COVID-19 pandemic and beyond
Monica Malik;Deepthi Valiyaveettil;Deepa Joseph
대한방사선종양학회 / 대한방사선종양학회지 제39권 제1호 / 2021 / 1-7 (7 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
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The coronavirus disease 2019 (COVID-19) pandemic has profoundly impacted cancer care, research and residency training in oncology worldwide. Many countries canceled exams, shortened their residency program and medical school tenure. Traditional teaching and learning method has faced significant disruption during this time and the situation has pushed us to adapt to e-learning. Most national and international cancer meetings were converted into a virtual platform during this time. E-learning ensures a safe environment to maintain education during a pandemic. Digital technology-based learning is likely to be used effectively in oncology training even after the pandemic ends. Stakeholders should work towards standardizing e-learning into routine educational modules and create a system of credibility and accountability.