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홈 > 분야별

의약학 > 종양학 (3,295건)

증례보고: 이하선에 발생한 다형선종 유래 피막내 암종 1예
증례보고: 이하선에 발생한 다형선종 유래 피막내 암종 1예
이승열(Seungyeol Lee);손황규(Hwangkyu Son);박호섭(Ho Sub Park);송창면(Chang Myeon Song)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 43-47 (5 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Among a variety of malignant types for parotid gland tumors, intracapsular carcinoma ex pleomorphic adenoma which is classified as a non-invasive tumor has been reported rarely. We report a case of a 69-years old patient, who presented with a left parotid mass that was detected 30 years ago. Fine needle aspiration biopsy result of the mass was “suggestive of pleomorphic adenoma”. Superficial partial parotidectomy was performed for the mass and the permanent pathologic finding was “intracapsular carcinoma ex pleomorphic adenoma” which was a salivary ductal carcinoma with well-preserved myoepithelial cells surrounding the malignant epithelial cell clusters. Surgical resection is the main treatment modality for the treatment of intracapsular carcinoma ex pleomorphic adenoma. Herein, we present the case with a review of literature.
예후가 좋지 않은 갑상선암에 대한 최신 치료 방침
예후가 좋지 않은 갑상선암에 대한 최신 치료 방침
이은경(Eun Kyung Lee)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 1-9 (9 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Thyroid cancer is one of the slow-growing tumors with excellent oncological outcomes. However, a small set of patients with unexpectedly severe outcomes are usually ignored. Anaplastic thyroid cancer (ATC) remains one of the most aggressive and lethal solid tumors. Recently, dabrafenib and trametinib combination therapy or neoadjuvant BRAF induction therapy has shown promising results. In addition, a combination of targeted drugs, immunotherapy, surgery, and radiation therapy can improve overall survival in ATC patients. Another disease for which there is no breakthrough treatment is radioactive iodine-refractory differentiated thyroid cancer (DTC). To date, multikinase inhibitors (sorafenib, lenvatinib) targeting the growth factor signaling pathway have been developed and approved as anticancer agents for patients with advanced DTC. This review includes results from multikinase inhibitors to the emergence of new target molecules, including rearrangements during transformation (RET) and tropomyosin receptor kinase (TRK).
광배근 근피판을 통한 두피 재건 및 두개골성형
광배근 근피판을 통한 두피 재건 및 두개골성형
윤태근(Taekeun Yoon);김상화(Sang Wha Kim)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 59-63 (5 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
The latissimus dorsi flap has high vascularity and is helpful for the reconstruction of infected areas. Herein, we present a patient with recurrent infections and soft-tissue defects who underwent cranial reconstruction using a free latissimus dorsi flap. The patient had undergone craniectomy and reconstruction using alloplastic bone 18 years previously. A scalp defect accompanied by infection occurred five years ago, and patient underwent reconstruction using a free flap at another hospital; however, the problem persisted. After debridement and bone flap removal, the right latissimus dorsi musculocutaneous flap was elevated, and the thoracodorsal artery and vein were anastomosed end-to-end to the right superficial temporal artery and vein. Methicillin-resistant Staphylococcus aureus was eradicated, and the flap survived. Cranioplasty was performed eight months later, and one year follow-up proceeded without complications. Effective reconstruction and cranioplasty are possible using the free latissimus dorsi musculocutaneous flap, even on scalp with persistent infections and soft-tissue defects.
귀밑샘 암종에서 생존 예측을 위한 임상병리 인자 분석 및 머신러닝 모델의 구축
귀밑샘 암종에서 생존 예측을 위한 임상병리 인자 분석 및 머신러닝 모델의 구축
곽승민(Seung Min Kwak);김세헌(Se-Heon Kim);최은창(Eun Chang Choi);임재열(Jae-Yol Lim);고윤우(Yoon Woo Koh);박영민(Young Min Park)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 17-24 (8 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Background/Objectives: This study analyzed the prognostic significance of clinico-pathologic factors including comprehensive nodal factors in parotid gland cancers (PGCs) patients and constructed a survival prediction model for PGCs patients using machine learning techniques. Materials & Methods: A total of 131 PGCs patients were enrolled in the study. Results: There were 19 cases (14.5%) of lymph nodes (LNs) at the lower neck level and 43 cases (32.8%) involved multiple level LNs metastases. There were 2 cases (1.5%) of metastases to the contralateral LNs. Intraparotid LNs metastasis was observed in 6 cases (4.6%) and extranodal extension (ENE) findings were observed in 35 cases (26.7%). Lymphovascular invasion (LVI) and perineural invasion findings were observed in 42 cases (32.1%) and 49 cases (37.4%), respectively. Machine learning prediction models were constructed using clinico-pathologic factors including comprehensive nodal factors and Decision Tree and Stacking model showed the highest accuracy at 74% and 70% for predicting patient’s survival. Conclusion: Lower level LNs metastasis and LNR have important prognostic significance for predicting disease recurrence and survival in PGCs patients. These two factors were used as important features for constructing machine learning prediction model. Our machine learning model could predict PGCs patient’s survival with a considerable level of accuracy.
귀에 발생한 가성낭종의 수술 후 실리콘 자석 압박 치료 사례 1예
귀에 발생한 가성낭종의 수술 후 실리콘 자석 압박 치료 사례 1예
설성훈(Seong Hoon Seol);정찬민(Chan Min Chung);박명철(Myong Chul Park)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 69-74 (6 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Endochondral pseudocyst of the ear is a rare, benign, non-inflammatory cystic disease. It is known that there are a variety of treatment methods for pseudocyst, which is mainly common in the scaphoid or triangular fossa of the ear. Pseudocyst formation is prevalent in the residual cavity of the ear. So, to prevent a recurrence, a surgical approach is also required, but management through compression is necessary after surgery. Applying a cube magnet to the lesion to press provides patient convenience and facilitates continuous management.
이하선 샘암종의 재발로 오인된 지선암 1예
이하선 샘암종의 재발로 오인된 지선암 1예
박솔(Sohl Park);윤주현(Ju Hyun Yun);고유진(Yu Jin Go);정수연(Soo Yeon Jung)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 37-41 (5 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Sebaceous carcinoma is extremely rare in the parotid gland. Recently, we experienced a case of carcinoma with sebaceous differentiation arising from the parotid gland in patient who was diagnosed as parotid adenoma carcinoma and underwent total parotidectomy. A 73-year-old male visited our department for the evaluation of 3-month history of infra-auricular mass combined with pain. Radiologic finding showed lobulated enhancing and solid mass with calcification in the right parotid gland. Initially, total parotidectomy with supraomohyoid neck dissection was performed. Pathological findings showed capsulated whitish mass with hemorrhage and cystic degeneration. Immunohistochemically, CK7, CK5/6, p63 were positive and CEA was negative. The intra-operative frozen section diagnosis was mucoepidermoid carcinoma. The permanent diagnosis was changed to adenocarcinoma, NOS(not otherwise specified). Fourteen months later, the newly developed mass was noticed on the operation bed. The mass was clinically diagnosed as recurred adenocarcinoma. Revision parotidectomy was performed and pathological findings revealed that the tumor was newly developed sebaceous carcinoma. We report a case of carcinoma with sebaceous differentiation in parotid gland with a review of literature.
요측전완과 이개전부 유리피판을 이용한 아전상악절제술과 비주결손의 동시 재건
요측전완과 이개전부 유리피판을 이용한 아전상악절제술과 비주결손의 동시 재건
윤태근(Taekeun Yoon);은석찬(Seokchan Eun);조성우(Sung-Woo Cho);이재서(Sung-Woo Cho)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 53-57 (5 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Reconstruction of subtotal maxillectomy defects with columella deficit is challenging. We report a unique case of facial reconstruction using a free radial forearm flap and a free preauricular flap for the maxillectomy and columella deficit. A 73-year-old woman was diagnosed with recurrent sebaceous carcinoma of the nose. We performed wide excision, including areas of the right cheek, nose, upper lip, maxilla, and columella. The resultant subtotal maxillectomy defect was reconstructed using a three-dimensional flap. First, a free radial forearm flap was transfered to resurface the nasal, oral, and external facial side. Second, a preauricular flap was positioned into the columella defect and anastomosed with the distal portion of the radial forearm flap pedicle. The two flaps survived, and the patient recovered uneventfully. We believe the radial forearm and preauricular double free flaps with the pedicle connection method were effective in reconstructing the present case of subtotal maxillectomy defect.
대한두경부종양학회지 제38권 제1호 목차
대한두경부종양학회지 제38권 제1호 목차
편집부
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 1-1 (1 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
* 이 논문은 저작권자의 요청으로 무료로 제공됩니다.
인유두종바이러스 관련 질환의 예방을 위한 남성 대상 백신의 임상적 유용성
인유두종바이러스 관련 질환의 예방을 위한 남성 대상 백신의 임상적 유용성
이세영(Sei Young Lee)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 11-16 (6 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
HHPV (Human Papillomavirus) is a DNA virus that can cause benign lesions, genitourinary cancer, and oropharyngeal cancer by penetrating the mucous membrane and skin. It is widely known to be transmitted mainly through sexual contact. As with many viral infections, vaccines have been developed to prevent infection with HPV. Currently, in many countries, HPV vaccines are mainly used for national immunization for women to prevent diseases that traditionally occur frequently in women, especially cervical cancer. However, since the vaccination rate is relatively low, many countries are struggling with ways to increase the vaccination rate. Meanwhile, the incidence of oropharyngeal cancer caused by HPV in men has been increasing recently. In the United States, the annual number of oropharyngeal cancers in men already exceeds the number of cervical cancers in women, so HPV infection in men has emerged as a major problem. Accordingly, interest in HPV vaccination in men has also increased, and studies on the effectiveness and necessity of vaccination of both women and men compared to women alone are being actively conducted. In this paper, the evidence of HPV vaccination for men will be reviewed through previous studies, and its validity and cost-effectiveness will be analyzed to bolster the clinical usefulness of HPV vaccination for men.
연구개 및 구개수 암종의 광범위 절제 및 국소 점막근 피판 재건술 1예
연구개 및 구개수 암종의 광범위 절제 및 국소 점막근 피판 재건술 1예
구가영(Ga Young Gu);이혜란(Hye Ran Lee);장전엽(Jeon Yeob Jang)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 31-35 (5 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
The soft palate of carcinoma limited to the uvular region is infrequent among oropharyngeal cancers. The oropharynx regulates swallowing and speech through dynamic motions. Failure to reconstruct after surgical resection of the oropharynx structure can lead to permanent velopharyngeal insufficiency. Therefore, suitable reconstruction is important in establishing proper functional outcomes while maintaining oncological safety. We present a case of a 66-year-old male who was diagnosed with oropharynx cancer limited in the uvula accompanied by lymph node metastasis. After surgical resection, reconstruction was performed with the united arrangement of bilateral palatal mucomuscular flap and superiorly based posterior pharyngeal flap. There was no aspiration or reflux after feeding and epithelialization completely occurred after 1 month postoperatively. We report a successful case that the reconstruction with the local flap described above could preserve proper oropharyngeal function after primary surgery in small-sized oropharyngeal cancer.
협점막에서 발생한 MALT 림프종 1예
협점막에서 발생한 MALT 림프종 1예
이현아(Hyeon A Lee);명재경(Jae Kyung Myung);태경(Kyung Tae)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 49-52 (4 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a lowgrade B-cell lymphoma that typically follows an indolent clinical course. It occurs in a variety of mucosal linings extranodal tissue, most commonly in the stomach. Other commonly involved sites include other parts of the gastrointestinal tract, thyroid, salivary gland, lung, lacrimal gland, synovium, dura mater, breast, skin, and eyes. It occurs very rarely in the buccal mucosa. A 50-year-old man came to the clinic while presenting a 5-month history of rightsided buccal mass. The incisional biopsy did not confirm the diagnosis of the lesion. He underwent complete excision of buccal mass for the diagnosis and treatment. The final pathology confirmed MALT lymphoma immunohistochemically. After surgery, he received radiotherapy with 30.6 Gy. There is no recurrence for 8 months after treatment. Herein we report a rare case of buccal MALT lymphoma with a review of the literature.
종격동내 위치한 갑상선 내 갑상설관 낭종: 증례 보고 및 문헌 고찰
종격동내 위치한 갑상선 내 갑상설관 낭종: 증례 보고 및 문헌 고찰
이찬미(Chan Mi Lee);홍용태(Yong Tae Hong)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 65-68 (4 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Thyroglossal duct cyst (TGDC) is the most common congenital cyst in the neck and usually presents in children. It is most commonly located at the infrahyoid level. However, intrathyroid TGDC in the adult is extremely rare and its pathogenesis remains unclear. Curiously, an intrathyroid TGDC was found on the lateral aspect of the inferior pole of the thyroid gland. Given the unique position of this lesion, and its capacity to stimulate other nodules in the thyroid, it should be differentiated from other lateral neck masses, such as: thymic cysts, branchial cleft cysts, cystic hygroma, lipomas, lymphadenopathies, cervical teratomas, and lymphomas. In this case, a separate cystic mass was found in the right inferior pole of the thyroid gland and extended to the mediastinum. We confirmed it as TGDC by pathology and histological examination.
자연경색을 동반한 부갑상선암 1예
자연경색을 동반한 부갑상선암 1예
금상연(Sang Yen Geum);박희준(Hee Jun Park);유재호(Jae Ho Yoo);김정규(Jeong Kyu Kim);이동원(Dong Won Lee)
대한두경부종양학회 / 대한두경부종양학회지 제38권 제1호 / 2022 / 25-29 (5 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 내과학
초록보기
Parathyroid carcinoma is very rare malignant neoplasm, accounting for less than 0.005% of all cancers. Most parathyroid carcinoma is a functioning tumor that causes hyperparathyroidism, leading to hypercalcemia. We report a parathyroid carcinoma case that was suspicious for spontaneous infarction of cancer, leading to resolution of hypercalcemia. A 29-year-old male visited our hospital presenting with right neck swelling and pain. He has been experiencing frequent urolithiasis for four years but laboratory tests showed normal serum calcium level. Right vocal cord paresis was identified with laryngoscopy. Ultrasonography revealed a 3.7 × 3.5 cm mass in the right thyroid containing a focal cystic portion. Computed tomography confirmed the presence of a low-density right thyroid mass. Right thyroid lobectomy was performed and pathological evaluation revealed parathyroid carcinoma with central necrosis. We report this very rare case with a literature review.
Radiation therapy in chronic hidradenitis suppurativa: case report
Radiation therapy in chronic hidradenitis suppurativa: case report
Pitchaya Sakyanun;Thirada Vongvanichvathana;Prasert Lertsanguansinchai
대한방사선종양학회 / 대한방사선종양학회지 제40권 제1호 / 2022 / 79-85 (7 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
초록보기
A 26-year-old female presented recurrent painful, carbuncles at both axillae for 10 years. It caused offensive odor and scar. Tissue diagnosis was chronic hidradenitis suppurativa. She was treated using antibiotics followed by multiple excisions with drainage but showed no improvement. Isotretinoin provided no benefit. She was socially isolated and experienced lower quality of life. Consequently, she was sent for radiation therapy. Computed tomography simulation was performed revealing an ulcer with deep chronic pus tracts at her axilla. Three-dimensional conformal radiation therapy was provided with 6 MV photon (7.5 Gy in 3 fractions) covering all ulcers and pus tracts. On the last day of radiation therapy, carbuncles and wounds at the left axilla exhibited much improvement without pus. Three months follow-up showed much improvement of the lesions. The skin was smoother without pus or odor. Radiation therapy was confirmed one treatment option for chronic hidradenitis suppurativa.
PIVKA-II as a surrogate marker for prognosis in patients with localized hepatocellular carcinoma receiving stereotactic body radiotherapy
PIVKA-II as a surrogate marker for prognosis in patients with localized hepatocellular carcinoma receiving stereotactic body radiotherapy
Ick Joon Cho;Jae-Uk Jeong;Taek-Keun Nam;Young-Eun Joo;Sung-Bum Cho;Yong-Hyub Kim;Ju-Young Song;Mee Sun Yoon;Sung-Ja Ahn;Woong-Ki Chung
대한방사선종양학회 / 대한방사선종양학회지 제40권 제1호 / 2022 / 20-28 (9 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
초록보기
Purpose: This study aimed to determine the correlation between protein induced by vitamin K absence or antagonist-II (PIVKA-II) and stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC). Materials and Methods: Sixty-one patients received SBRT between 2015 and 2020 with a median dose of 48 Gy (range, 39 to 60 Gy) with a median of 4 fractions. Changes in tumor markers before and after SBRT were analyzed. Results: The median follow-up period was 31 months (range, 12 to 64 months). The estimated 2-year in-field failure-free survival, progression-free survival (PFS), and overall survival rates were 82.0%, 39.3%, and 96.7%, respectively. Patients with decreased PIVKA-II levels through SBRT had significantly few in-field failures (p = 0.005). Patients with PIVKA-II levels of ≤25 mAU/mL after SBRT had significantly long PFS (p = 0.004). Conclusion: PIVKA-II could be a useful surrogate marker for response or survival outcomes in patients with localized HCC receiving SBRT.
Optimal positive lymph node ratio showing the benefit of postoperative radiotherapy in pathologic N2 non-small cell lung cancer: an exploratory study using the Surveillance, Epidemiology, and End Results data
Optimal positive lymph node ratio showing the benefit of postoperative radiotherapy in pathologic N2 non-small cell lung cancer: an exploratory study using the Surveillance, Epidemiology, and End Results data
Shiho Lee;O Kyu Noh
대한방사선종양학회 / 대한방사선종양학회지 제40권 제1호 / 2022 / 37-44 (8 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
초록보기
Purpose: This study aimed to identify the clinical parameters having the beneficial effect of postoperative radiotherapy (PORT) in pathologic N2 (pN2) non-small cell lung cancer (NSCLC) using the Surveillance, Epidemiology, and End Results (SEER) data. Materials and Methods: Among non-metastatic NSCLC patients in the SEER data, we included patients who diagnosed after 2002, who confirmed as pN2 after lobectomy or pneumonectomy, and who coded as underwent PORT or observation. Patients who survived less than 4 months of diagnosis were excluded in consideration of the perioperative mortality. After performing propensity score matching (PSM) on the selected patients, we compared PORT group with surgery alone group. We also performed exploratory subgroup analysis to find patients who could benefit from PORT. Results: Among the selected 4,456 patients, 1,729 patients received PORT, and 2,727 patients did not. There was no survival benefit of PORT in all patients with pN2 disease (hazard ratio [HR] = 1.03, p = 0.5). In subgroup analyses, the patients with a positive lymph node (LN) ratio of 60%-80% showed the significant benefit of PORT (HR = 0.71, p = 0.002). Conclusion: PORT did not show the significant survival benefit in patients with pN2 disease after correcting the confoundedness in the SEER data. However, a specific range of LN ratios can be a potential indicator maximizing the survival benefit of PORT.
PA1 cells containing a truncated DNA polymerase β protein are more sensitive to gamma radiation
PA1 cells containing a truncated DNA polymerase β protein are more sensitive to gamma radiation
Anutosh Patra;Anish Nag;Anindita Chakraborty;Nandan Bhattacharyya
대한방사선종양학회 / 대한방사선종양학회지 제40권 제1호 / 2022 / 66-78 (13 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
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Purpose: DNA polymerase β (Polβ) acts in the base excision repair (BER) pathway. Mutations in DNA polymerase β (Polβ) are associated with different cancers. A variant of Polβ with a 97 amino acid deletion (PolβΔ), in heterozygous conditions with wild-type Polβ, was identified in sporadic ovarian tumor samples. This study aims to evaluate the gamma radiation sensitivity of PolβΔ for possible target therapy in ovarian cancer treatment. Materials and Methods: PolβΔ cDNA was cloned in a GFP vector and transfected in PA1 cells. Stable cells (PA1PolβΔ) were treated with 60Co sourced gamma-ray (0-15 Gy) to investigate their radiation sensitivity. The affinity of PolβΔ with DNA evaluated by DNA protein in silico docking experiments. Results: The result showed a statistically significant (p < 0.05) higher sensitivity towards radiation at different doses (0-15 Gy) and time-point (48-72 hours) for PA1PolβΔ cells in comparison with normal PA1 cells. Ten Gy of gamma radiation was found to be the optimal dose. Significantly more PA1PolβΔ cells were killed at this dose than PA1 cells after 48 hours of treatment via an apoptotic pathway. The in silico docking experiments revealed that PolβΔ has more substantial binding potential towards the dsDNA than wild-type Polβ, suggesting a possible failure of BER pathway that results in cell death. Conclusion: Our study showed that the PA1PolβΔ cells were more susceptible than PA1 cells to gamma radiation. In the future, the potentiality of ionizing radiation to treat this type of cancer will be checked in animal models.
Limited field adaptive radiotherapy for glioblastoma: changes in target volume and organ at risk doses
Limited field adaptive radiotherapy for glioblastoma: changes in target volume and organ at risk doses
Öznur Şenkesen;Evrim Tezcanlı;Mehmet Ufuk Abacıoğlu;Zeynep Özen;Derya Çöne;Halil Küçücük;Evren Ozan Göksel;Alptekin Arifoğlu;Meriç Şengöz
대한방사선종양학회 / 대한방사선종양학회지 제40권 제1호 / 2022 / 9-19 (11 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
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Objective: This study aimed to investigate the tumor volume changes occurring during limited-field radiotherapy (RT) for glioblastoma patients and whether a volume-adapted boost planning approach provided any benefit on tumor coverage and normal tissue sparing. Materials and Methods: Twenty-four patients underwent simulation with magnetic resonance (MR) and computed tomography (CT) scans prior to RT (MR_initial, CT_initial) and boost treatment (MR_adapt, CT_adapt). For the boost phase, MR_initial and MR_adapt images were used to delineate GTV2 and GTV2_adapt, respectively. An initial boost plan (Plan_initial) created on CT_initial for PTV2 was then reoptimized on CT_adapt by keeping the same optimization and normalization values. Plan_adapt was generated on CT_adapt for PTV2_adapt volume. Dose volume histogram parameters for target volumes and organs-at-risk were compared using these boost plans generated on CT_adapt. Plan_initial and Plan_adaptive boost plans were summed with the first phase plan and the effect on the total dose was investigated. Results: Target volume expansion was noted in 21% of patients while 79% had shrinkage. The average difference for the initial and adaptive gross tumor volume (GTV), clinical target volume (CTV), and planning target volume (PTV) volumes were statistically significant. Maximum dose differences for brainstem and optic chiasm were significant. Healthy brain tissue V10 and ipsilateral optic nerve maximum doses were found to decrease significantly in Plan_adaptive. Conclusion: Results of this study confirm occurrence of target volume changes during RT for glioblastoma patients. An adaptive plan can provide better normal tissue sparing for patients with lesion shrinkage and avoid undercoverage of treatment volumes in case of target volume expansion especially when limited-fields are used.
Immunomodulatory effect of splenectomy in lung cancer mouse xenograft models receiving radiation therapy
Immunomodulatory effect of splenectomy in lung cancer mouse xenograft models receiving radiation therapy
Yeeun Kim;Changhoon Choi;Jee Hyun Park;Won-Gyun Ahn;Sung-Won Shin;Shin-Yeong Kim;Jae Myoung Noh
대한방사선종양학회 / 대한방사선종양학회지 제40권 제1호 / 2022 / 53-65 (13 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학
초록보기
Purpose: This study aims to investigate the effect of splenectomy on radiation-mediated growth inhibition and immune modulation in lung cancer xenograft models. Materials and Methods: Human non-small cell lung cancer H1299 cells and murine Lewis lung carcinoma LL/2-luc cells were injected into the right hind leg of BALB/c-nude mice and C57BL/6 mice, respectively. Splenectomy or sham operation was performed prior to tumor cell injection or before and after irradiation during tumor growth. Irradiation was delivered with 2-3 fractions of 6 Gy X-ray using a linear accelerator. Flow cytometry analysis was performed for immune cell profiling. Results: Splenectomy prior to tumor injection or at early stage inhibited growth of LL/2-luc tumors but not that of H1299 tumors; however, it did not enhance the antitumor effect of radiation regardless of intervention timing. Flow cytometry analysis showed monocytic myeloid-derived suppressor cells (MDSCs) and activated CD8+ T cells increased after irradiation in the tumors of splenectomized mice, compared to those of sham-operated mice. Administration of anti-PD-1 (programmed death-1) antibodies improved the ability of splenectomy to attenuate the growth of irradiated tumors. Conclusion: Splenectomy has paradoxical effects on radiation-induced tumor growth inhibition, depending on tumor types and intervention timing, but it has an immune-modulating effect when combined with radiation.
Comment on “Abscopal effect in the radio and immunotherapy”
Comment on “Abscopal effect in the radio and immunotherapy”
François Fabi
대한방사선종양학회 / 대한방사선종양학회지 제40권 제1호 / 2022 / 86-87 (2 pages)
의약학>종양학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 방사선과학