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의약학 > 소아과학 (1,044건)

Significance of Polyspikes on Electroencephalography in Children with Focal Epilepsy
Significance of Polyspikes on Electroencephalography in Children with Focal Epilepsy
Ara Ko;Juhyun Kong;Furkat Samadov;Akmal Mukhamedov;Young Mi Kim;Yun-Jin Lee;Sang Ook Nam
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제2호 / 2022 / 45-52 (8 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: Epilepsy is one of the most common neurological disorders in both adults and children. After detailed history-taking, electroencephalography (EEG) is the most important investigation in the evaluation of epilepsy patients. Polyspikes, defined as a sequence of two or more spikes, are among the findings that can be seen on EEGs of epilepsy patients, but the literature on their significance in focal epilepsy patients is scarce. Therefore, in the current study, we investigated the significance of polyspikes on EEG in childhood focal epilepsy. Methods: A retrospective analysis was conducted of data from children who were diagnosed with focal epilepsy and received anti-seizure medications at Pusan National University Children’s Hospital. Results: Among the 1,125 children included in this study, 468 (41.6%) showed interictal polyspikes on their EEGs. In the multivariate analysis, only the presence of brain magnetic resonance imaging (MRI) abnormalities was significantly associated with the presence of interictal polyspikes on EEGs. Among patients with brain MRI abnormalities, localized polyspikes were significantly associated with focal cortical dysplasia, while multifocal polyspikes were significantly associated with perinatal insults (hypoxic-ischemic encephalopathy and destructive encephalomalacia). Conclusion: Focal epilepsy patients with interictal polyspikes were more likely to have a structural etiology. Furthermore, patients with localized polyspikes were more likely to have focal cortical dysplasia as the structural etiology, while patients with multifocal polyspikes were more likely to have perinatal insults as the structural etiology. This study demonstrates that focal polyspikes can be used as markers of the possible presence of a structural etiology in routine practice.
Next-Generation Sequencing for the Early Diagnosis of Adolescent Patients with Suspected Charcot-Marie-Tooth Disease: A Case Series
Next-Generation Sequencing for the Early Diagnosis of Adolescent Patients with Suspected Charcot-Marie-Tooth Disease: A Case Series
Jongdae Park;Sanghoon Kim;Ji Young Ahn;Chul Hyun Park;Saeyoon Kim
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제2호 / 2022 / 64-66 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Annals of Child Neurology vol.30 no.2 목차
Annals of Child Neurology vol.30 no.2 목차
편집부
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제2호 / 2022 / 1-1 (1 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
* 이 논문은 저작권자의 요청으로 무료로 제공됩니다.
An 8q24.11q24.13 Microdeletion Encompassing EXT1 in a Boy with Autistic Spectrum Disorder, Intellectual Disability, and Multiple Hereditary Exostoses
An 8q24.11q24.13 Microdeletion Encompassing EXT1 in a Boy with Autistic Spectrum Disorder, Intellectual Disability, and Multiple Hereditary Exostoses
Min Jeong Kim;Yunjin Lee;Sang Ook Nam;Young Mi Kim
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제2호 / 2022 / 61-63 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Pediatric-Onset CLIPPERS: A Case Report and Literature Review
Pediatric-Onset CLIPPERS: A Case Report and Literature Review
Vanessa Wan Mun Lee;Teik Beng Khoo;Che Zubaidah Binti Che Daud;Kartikasalwah Binti Abdul Latif
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제2호 / 2022 / 70-74 (5 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Effect of the COVID-19 Pandemic on Headache in Pediatric Migraine Patients at a Single Tertiary Center
Effect of the COVID-19 Pandemic on Headache in Pediatric Migraine Patients at a Single Tertiary Center
Taek Jin Lim;Juhyun Kong;Sang Ook Nam;Shin Yun Byun;Sungsu Jung;Gyu Min Yeon;Yun-Jin Lee
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제2호 / 2022 / 53-60 (8 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: The aim of this study was to evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on children and adolescents with migraine. Methods: This longitudinal cohort study enrolled children and adolescents with migraine from the Department of Pediatric Neurology at our hospital from January 2017 to June 2021. Self-reported data from individual headache diaries were used. The patients were questioned about their headache frequency and intensity, stress, physical activity, changes in mood and sleep, and their school and home lives during the COVID-19 pandemic. The Pediatric Migraine Disability Assessment (Ped-MIDAS) scoring system was applied to assess headache-related disability. Results: In total, 325 pediatric migraine patients (mean age 12.8±5.6 years, 62.5% female) were included in this study. The average monthly frequency of migraine headaches was 2.17±1.32 and 4.62±3.29 before and during the COVID-19 pandemic (P<0.001), respectively. The Ped-MIDAS score was obtained for 207 patients both before and during the pandemic, and the total score slightly increased from 13.8 to 14.7 points (P=0.295). Sixty patients (18.5%) showed significantly worsening migraine headaches. Younger age (P=0.017), mood deterioration (P<0.001), sleep problems (P<0.001), increased acute medication use (P=0.010), and larger changes in the Ped-MIDAS score (P=0.002) were significantly associated with worsening headache in the logistic regression analysis. Conclusion: Headache attacks in children and adolescents with migraine were more frequent during the COVID-19 pandemic than before it. Worsening headaches could be independently attributed to younger age, mood deterioration, and poor sleep during the COVID-19 pandemic.
Intravenous Ferric Carboxymaltose as Rescue Therapy in Severe Breath Holding Spells: A Case Report and Literature Review
Intravenous Ferric Carboxymaltose as Rescue Therapy in Severe Breath Holding Spells: A Case Report and Literature Review
Hee Jeong Yun;Won Seop Kim;Jon Soo Kim
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제2호 / 2022 / 67-69 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
A Juvenile Case of Primary Sjögren Syndrome Presenting as Limb Weakness
A Juvenile Case of Primary Sjögren Syndrome Presenting as Limb Weakness
Soo Jin Baik;Tae Hwan Han;Sang Youn Jung;Ji-In Bang;Kyu Young Chae
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제1호 / 2021 / 38-41 (4 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Characteristics of Functional Speech Sound Disorders in Korean Children
Characteristics of Functional Speech Sound Disorders in Korean Children
Min Jeong Han;Sun Jun Kim
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제1호 / 2021 / 8-16 (9 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: A speech sound disorder (SSD) is defined as the presence of a problem with articulation and phonological processes in a child. This study analyzed the clinical characteristics of Korean patients with functional SSDs without any neuromuscular abnormalities. Methods: The medical records of patients aged 36 to 72 months old who were diagnosed with SSDs were retrospectively reviewed. SSD patients who scored less than 85 in the U-Tap test were divided into two groups according to their receptive language scores on the Preschool Receptive- Expressive Language Scale (PRES)/the Sequenced Language Scale for Infants (SELSI). Results: Sixty-seven percent of patients with language impairment (LI) who were diagnosed with an SSD initially visited the hospital for a delay in language development (n=18, 66.7%). Among children with only an SSD, 26.7% (n=8) of the patients recognized it as a language developmental problem. All SSD patients had substitution errors in the onset of initial syllables (SSD, SSD+LI: 100%; typical development [TD]: 37.5%). Of particular note, SSD children with LI had more omission errors (55.6%) than patients with SSD only (16.7%). SSD patients had higher error rates than TD children in all consonants except for the glottal element (P<0.01). The lower the U-Tap score of SSD patients, the lower their expressive language score (P<0.001). Conclusion: A high percentage of children with SSD initially visited the hospital for the treatment of language development delays. Articulation tests are essential for children who suffer from language delay. Furthermore, since incorrect articulation can lead to delays in expressive language development, early interventions should be considered.
Unilateral and Reversible Hypoglossal Nerve Palsy Due to Infectious Mononucleosis
Unilateral and Reversible Hypoglossal Nerve Palsy Due to Infectious Mononucleosis
Ji-Hoon Na;Ji Hyen Lee
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제1호 / 2021 / 24-26 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Neonatal-Onset PIGT Encephalopathy: A Rare Korean Case with Hypophosphatasia
Neonatal-Onset PIGT Encephalopathy: A Rare Korean Case with Hypophosphatasia
Min Jun Chun;Yeon Sook Moon;Woo Ri Jang;Jong Hee Chae;Young Se Kwon
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제1호 / 2021 / 35-37 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Development of a Risk Predictive Scoring System for Epilepsy in Infants with Paroxysmal Motor Events: A Retrospective Single-Center Study
Development of a Risk Predictive Scoring System for Epilepsy in Infants with Paroxysmal Motor Events: A Retrospective Single-Center Study
Han Jun Kim;Han Na Jang;Hyunji Ahn;Mi-Sun Yum;Tae-Sung Ko
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제1호 / 2021 / 1-7 (7 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: Paroxysmal motor events are common clinical symptoms in infants visiting pediatric neurology clinics. Due to the heterogeneous clinical symptoms and the difficulty of interpreting electroencephalography (EEG) in infants, differentiating paroxysmal motor events from epileptic events is challenging. This study aimed to investigate the risk factors for the diagnosis of epilepsy in infants and to develop a scoring system that predicts the risk of epilepsy. Methods: We retrospectively analyzed data from patients who presented with paroxysmal motor events in infancy between January 2008 and December 2009 at Asan Medical Center. Electronic medical records were reviewed for patients’ demographics, medical history, clinical characteristics associated with specific situations, and motor symptoms. Laboratory findings, EEG, and brain magnetic resonance imaging were also reviewed. Results: In total, 111 infants with paroxysmal motor events were enrolled. Non-epileptic paroxysmal motor events (NEPMs) were associated with specific situations (P<0.001). Patients with epilepsy were likely to have focal motor symptoms (P=0.08), a medical history of a neurologic disorder, and/or a family history of epilepsy (P<0.05). A risk scoring system was developed based on these risk factors; using this system, infants with 2 or more points could be diagnosed with epilepsy with 61.76% sensitivity and 88.31% specificity. Conclusion: Infants with paroxysmal motor events were more likely to be diagnosed with NEPMs than with epilepsy. An absence of specific situations for paroxysmal events, focal motor seizures, and a medical history of another illness were associated with the final diagnosis of epilepsy.
Usefulness of Magnetic Resonance Spectroscopy for the Initial Diagnosis of Mitochondrial DNA-Associated Leigh Syndrome
Usefulness of Magnetic Resonance Spectroscopy for the Initial Diagnosis of Mitochondrial DNA-Associated Leigh Syndrome
Ji-Hoon Na;Je Hee Shin;Hyunjoo Lee;Young-Mock Lee
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제1호 / 2021 / 17-23 (7 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: Diagnosing Leigh syndrome (LS), a representative mitochondrial disease, remains challenging. Mitochondrial DNA (mtDNA)-associated LS, which is maternally inherited, has relatively well-known genetic variants. We evaluated the usefulness of brain magnetic resonance spectroscopy (MRS) for the initial diagnosis of mtDNA-associated LS using data from LS patients. Methods: The study involved LS patients who visited Gangnam Severance Hospital between 2006 and 2018. Based on patients’ clinical findings, genetic evaluations, brain magnetic resonance imaging, and brain MRS findings, 24 mtDNA-associated and 49 gene-negative LS patients were included in the current study. Lactate peaks and decreased N-acetyl aspartate (NAA) peaks in brain MRS were compared between both groups. Results: In total, 11 mtDNA mutation subtypes were detected. Our findings showed a higher proportion of brain MRS abnormalities in mtDNA-associated LS patients than in gene-negative LS patients, but no statistically significant differences were observed between the two groups (lactate peak, P=0.080; decreased NAA peak, P=0.115). Conclusion: Brain MRS is currently limited as an initial diagnostic test for mtDNA-associated LS. However, it may be a useful non-invasive test for the follow-up evaluation of mtDNA-associated LS treatment. Ultra-high-field MRS technology is expected in the future.
Distinctive Severe Ocular Abnormalities and Epilepsy Accompanied by a Novel ZEB2 Mutation in a Child with Mowat-Wilson Syndrome
Distinctive Severe Ocular Abnormalities and Epilepsy Accompanied by a Novel ZEB2 Mutation in a Child with Mowat-Wilson Syndrome
Soyoung Park;Yun Jung Hur;Jin Sook Yoon;Mi-Ae Jang
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제1호 / 2021 / 31-34 (4 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Mineralizing Angiopathy: An Uncommon Cause of Pediatric Stroke with Good Outcome
Mineralizing Angiopathy: An Uncommon Cause of Pediatric Stroke with Good Outcome
Divya Nagabushana;Supraja Chandrasekhar;Gurudutt Avathi Venkatesha
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제1호 / 2021 / 42-43 (2 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
High-Dose Prednisolone Therapy for Lennox–Gastaut Syndrome Caused by Fentanyl Intoxication-Induced Toxic Leukoencephalopathy
High-Dose Prednisolone Therapy for Lennox–Gastaut Syndrome Caused by Fentanyl Intoxication-Induced Toxic Leukoencephalopathy
Hui Jin Shin;Ji-Hoon Na;Hyunjoo Lee;Young-Mock Lee
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제30권 제1호 / 2021 / 27-30 (4 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
An Indian Family with Childhood Onset of Striatal Necrosis
An Indian Family with Childhood Onset of Striatal Necrosis
Divya Nagabushana;Praveen-Kumar Srikanteswara;Archana Netto;Karthik Nagaraj
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제29권 제4호 / 2021 / 176-179 (4 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Split-Hand/Foot Malformation and Subependymal Heterotopia Caused by a DLX5 Gene Mutation: A Case Report
Split-Hand/Foot Malformation and Subependymal Heterotopia Caused by a DLX5 Gene Mutation: A Case Report
Jun Hee Shin;Min Jeong Han;Sun Jun Kim
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제29권 제4호 / 2021 / 199-201 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Effects of Occipital Nerve Block in Pediatric Patients with Occipital Region Headache
Effects of Occipital Nerve Block in Pediatric Patients with Occipital Region Headache
Hey-Joon Son;Kon-Hee Lee
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제29권 제4호 / 2021 / 168-172 (5 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: The aim of this study was to investigate the effects of occipital nerve block (ONB) in pediatric patients with headache in the occipital region. Methods: Among 302 patients who visited our headache clinic during a 2-year period, we retrospectively reviewed the charts of 26 patients who complained of primary headache in the occipital region, and divided them into two groups according to the main treatment: ONB or oral drug treatment (ODT). Results: The mean age of the 26 patients was 11.7±3.2 years. No statistically significant differences were found between the ONB and ODT groups in age, sex, sites of pain, duration of having experienced symptoms, and the duration, frequency, and severity of episodes (P>0.05). There was no statistically significant difference in remission between the ONB and ODT groups. However, in the ONB group, the time taken to achieve remission was significantly shorter than in the ODT group (P<0.05). Additionally, in the ONB group, the duration of medication and the period of outpatient treatment were significantly shorter than in the ODT group (P<0.05). Conclusion: In this study, ONB reduced the time taken to achieve remission and shortened the period of treatment. Thus, ONB should be considered in pediatric patients with headache in the occipital region.
Stroke-Like Episodes Associated with Coronavirus Disease 2019 in a Child with MELAS Syndrome
Stroke-Like Episodes Associated with Coronavirus Disease 2019 in a Child with MELAS Syndrome
Woo-Jin Kim;Mi-Sun Yum;Min-Jee Kim;Han-Na Jang;Tae-Sung Ko
대한소아신경학회 / Annals of Child Neurology(구 대한소아신경학회지) 제29권 제4호 / 2021 / 183-185 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학