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홈 > 분야별

의약학 > 소아과학 (1,009건)

Comparison of the Demographics and Ratio of Rotavirus-Associated Benign Convulsions with Mild Gastroenteritis to Rotavirus Gastroenteritis before and after Rotavirus Vaccination over a Period of 20 Years
Comparison of the Demographics and Ratio of Rotavirus-Associated Benign Convulsions with Mild Gastroenteritis to Rotavirus Gastroenteritis before and after Rotavirus Vaccination over a Period of 20 Years
Yeong Seok Lee;Dong Hyun Kim;Dong Jun Ha;Young Se Kwon
대한소아신경학회 / Annals of Child Neurology 제29권 제2호 / 2021 / 75-82 (8 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: Through a study of rotavirus gastroenteritis (RVGE) cases experienced over 20 years at our center, we aimed to investigate changes in the ratio of rotavirus-associated benign convulsions with mild gastroenteritis (RaCwG) to RVGE and in patients’ demographics after rotavirus vaccination. Methods: We analyzed the data of patients aged ≤6 years who visited Inha University Hospital between January 1999 and December 2019 and were confirmed to have RVGE. Patients were divided according to whether they had convulsions with mild gastroenteritis, and their demographics were compared. The yearly and monthly ratios of RaCwG to RVGE were evaluated. To investigate the effects of rotavirus vaccination, data regarding demographics and prevalence were divided into periods I (pre-vaccination, 1999–2009) and II (post-vaccination, 2010–2019) and compared. Results: Altogether, 2,100 children had RVGE, and 50 (2.4%) had RaCwG. RaCwG occurred frequently every 4 to 6 years. Although the total number of RVGE and RaCwG cases significantly decreased in period II versus period I, the ratio of RaCwG to RVGE did not differ between the two groups (P=0.921). The age distribution shifted upwards in period II versus period I (P=0.001), but the sex ratio and seasonal distribution showed no significant difference. Conclusion: Considering that the ratio of RaCwG to RVGE is dynamic, an increase in the ratio of RaCwG may be possible in the future. Although there was no change in the ratio of RaCwG to RVGE, the number of RVGE and RaCwG patients decreased simultaneously, suggesting that rotavirus vaccination was effective in preventing RaCwG.
Toxic Leukoencephalopathy by Accidental Oral Ingestion of an Infant’s Fentanyl Patch
Toxic Leukoencephalopathy by Accidental Oral Ingestion of an Infant’s Fentanyl Patch
Hyeji Lim;Hyunjoo Lee;Young-Mock Lee
대한소아신경학회 / Annals of Child Neurology 제29권 제2호 / 2021 / 93-94 (2 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
A MAST1 Mutation Underlying Mega-Corpus Callosum Syndrome with Extended Phenotypes: The First Case in Korea
A MAST1 Mutation Underlying Mega-Corpus Callosum Syndrome with Extended Phenotypes: The First Case in Korea
Yun Jung Hur;Woo Yeong Chung;Yun-Jung Lim;Sooyoung Park;Kyung Ran Jun
대한소아신경학회 / Annals of Child Neurology 제29권 제2호 / 2021 / 101-104 (4 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
FLNA Duplication in a Female Infant with Periventricular Nodular Heterotopia
FLNA Duplication in a Female Infant with Periventricular Nodular Heterotopia
Nam Shik Kong;Hyunjoo Lee;Young-Mock Lee
대한소아신경학회 / Annals of Child Neurology 제29권 제2호 / 2021 / 91-92 (2 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Anticonvulsants for the Treatment of Hemichorea after Surgical Revascularization in Adolescent Patients with Moyamoya Disease
Anticonvulsants for the Treatment of Hemichorea after Surgical Revascularization in Adolescent Patients with Moyamoya Disease
Ga Hee Lee;Dong Hyun Kim;Hyeon Seon Park;Woo Ri Jang;Young Se Kwon
대한소아신경학회 / Annals of Child Neurology 제29권 제2호 / 2021 / 98-100 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Clinical and Genetic Spectrum of STXBP1 Encephalopathy in the Korean Pediatric Population
Clinical and Genetic Spectrum of STXBP1 Encephalopathy in the Korean Pediatric Population
Woo Joong Kim;Young Kyu Shim;Young Jun Ko;Soo Yeon Kim;Hunmin Kim;Byung Chan Lim;Hee Hwang;Jieun Choi;Ki Joong Kim;Jong-Hee Chae
대한소아신경학회 / Annals of Child Neurology 제29권 제2호 / 2021 / 68-74 (7 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: Syntaxin-binding protein 1 (STXBP1) mutations are known to result in various phenotypes including Ohtahara syndrome, West syndrome, and autism, collectively referred as STXBP1 encephalopathy. This study aimed to expand our understanding of the genotype–phenotype spectrum of STXBP1 encephalopathy in the Korean pediatric population. Methods: Ten patients with STXBP1 mutations were enrolled for a retrospective chart review. The patients were investigated for developmental delay of unknown cause and epileptic encephalopathy at a single center. Results: Ten different STXBP1 mutations were identified. Three mutations had not previously been reported (c.1212A>C, c.1497C>G, c1030-2A>G). Eight patients showed early-onset epileptic encephalopathy as the main feature, while the main feature was developmental delay and non-epileptic movements in two patients. The most commonly seen electroencephalographic change was focal/ multifocal epileptiform discharges, which were observed in nine patients (90%). The classical burst-suppression pattern was observed in four patients, two of which evolved to show hypsarrthymia. All patients with seizures had drug-resistant epilepsy. The patients suffered from severe developmental delay regardless of seizure frequency. Six patients showed an associated movement disorder or behavioral disorder. Conclusion: This study describes the STXBP1 encephalopathy patients in Korean pediatric population, further expanding knowledge of its phenotype spectrum.
Characteristics of Meningitis in Febrile Infants Aged ≤90 Days
Characteristics of Meningitis in Febrile Infants Aged ≤90 Days
Kyu Un Cho;Su Jeong You
대한소아신경학회 / Annals of Child Neurology 제29권 제2호 / 2021 / 83-90 (8 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: This study evaluated the clinical and laboratory characteristics of infants ≤90 days old with meningitis who presented to the hospital with a fever. We also investigated whether initial C-reactive protein levels and white blood cell counts were reliable predictors of bacterial meningitis. Methods: The medical records of 1,151 infants aged ≤90 days who visited our hospital with a fever between October 2009 and October 2019 were retrospectively evaluated. Results: Of the 1,151 patients, 274 (23.8%) had meningitis (bacterial, n=7; viral, n=206; pleocytosis in the cerebrospinal fluid, n=136). Thirty-seven viral meningitis patients (18.0%) had a positive polymerase chain reaction result without pleocytosis in the cerebrospinal fluid. The patients without pleocytosis were significantly younger. Among the patients with only pleocytosis, 46 had a urinary tract infection, 22 had other viral infections, and the etiology was unknown in 68. Among patients with urinary tract infections, infants without pleocytosis were younger than those with pleocytosis. Low white blood cell counts (<5,000/㎣) were more frequently found in bacterial meningitis patients (n=7) than in viral meningitis patients. Furthermore, there were normal C-reactive protein levels (42.9%) and no pleocytosis (20%) in some cases of bacterial meningitis. Conclusion: Our findings show that meningitis is not uncommon among infants ≤90 days old who were brought to the hospital with complaints of fever. Furthermore, younger patients may not have cerebrospinal fluid pleocytosis, even if they have bacterial meningitis. Therefore, the patient’s condition should be monitored closely and, if necessary, a re-examination should be considered.
Unusual Clinical Presentations in a Patient with Novel ADCK3 Variants
Unusual Clinical Presentations in a Patient with Novel ADCK3 Variants
Eui Ra Huh;Hyunjoo Lee;Young-Mock Lee
대한소아신경학회 / Annals of Child Neurology 제29권 제2호 / 2021 / 95-97 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Once-Daily Extended-Release Levetiracetam Improves Medication Compliance in Adolescent Epilepsy Patients
Once-Daily Extended-Release Levetiracetam Improves Medication Compliance in Adolescent Epilepsy Patients
Seung Yeon Jung;Yoon Young Yi;Joon Won Kang
대한소아신경학회 / Annals of Child Neurology 제29권 제2호 / 2021 / 61-67 (7 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: Since pharmacologic agents are the mainstay of epilepsy treatment, drug compliance is one of the most important factors in seizure control. Once-daily levetiracetam (LEV) has been proven to have the same efficacy as that of an immediate-release (IR) formulation. A reduced number of doses may improve drug compliance and patient satisfaction. The aim of this study was to assess drug compliance and patient satisfaction when changing from IR to an extended-release (ER) formulation. Methods: Adolescent patients diagnosed with epilepsy who were taking LEV from 2018 to 2020 were included in this study. Compliance charts were reviewed retrospectively. We compared the frequency of seizure occurrence with the frequency of skipping doses and adverse effects before and after changing formulations. Changes in subjective compliance and satisfaction were also investigated. Results: Among 585 patients taking LEV, 44 were included in this study. The average age of the included patients was 16.4±2.0 years. There was no significant change in the average seizure frequency (P=0.491) after switching formulations. Objective compliance based on chart records significantly improved after switching formulations (P=0.021). Additionally, 26 of 44 patients mentioned how they felt about switching formulations, of whom 25 (96.2%) were satisfied with the ER formulation. Thirteen of 24 patients (54.2%) reported better compliance. Conclusion: Our study shows that the efficacy of LEV ER was similar to that of the IR formulation. The reduced number of medication doses improved patient satisfaction and medication compliance. LEV ER may be preferable in adolescent epilepsy patients.
Clinical Manifestations of Hydranencephaly: A Case in Monochorionic-Diamniotic Twin
Clinical Manifestations of Hydranencephaly: A Case in Monochorionic-Diamniotic Twin
Bit Gyeol Kim;Kyoung Ja Lim;Yoon Young Yi
대한소아신경학회 / Annals of Child Neurology 제29권 제2호 / 2021 / 105-107 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Hyperkinesia after High-Dose Prednisolone Therapy in a Patient with West Syndrome
Hyperkinesia after High-Dose Prednisolone Therapy in a Patient with West Syndrome
Miran Lee;Juhyun Kong;Ara Ko;Yun Jin Lee;Sang Ook Nam
대한소아신경학회 / Annals of Child Neurology 제29권 제1호 / 2021 / 37-39 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Refractory Seizure with Autosomal Dominant Hypocalcemia with Hypercalciuria with a CASR Mutation Detected Using Whole Exome Sequencing
Refractory Seizure with Autosomal Dominant Hypocalcemia with Hypercalciuria with a CASR Mutation Detected Using Whole Exome Sequencing
Seong Bae Ahn;Sung Han Shim;Eun-Gyong Yoo;Mo Kyung Jung;Kyu Young Chae
대한소아신경학회 / Annals of Child Neurology 제29권 제1호 / 2021 / 47-50 (4 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Screening of Tuberous Sclerosis-Associated Neuropsychiatric Disorders in Korea Using the TAND Checklist
Screening of Tuberous Sclerosis-Associated Neuropsychiatric Disorders in Korea Using the TAND Checklist
Soyoung Park;Soyong Eom;Hoon-Chul Kang;Joon Soo Lee;Heung Dong Kim;Hee Jung Chung
대한소아신경학회 / Annals of Child Neurology 제29권 제1호 / 2021 / 8-14 (7 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: The present study aimed to elucidate the clinical characteristics of children with tuberous sclerosis complex (TSC) in Korea using the Tuberous Sclerosis-Associated Neuropsychiatric Disorders (TAND) checklist to evaluate the comorbidities of neurocognitive and socioemotional problems in the Korean clinical setting. Methods: A survey based on the TAND checklist was administered to 58 children with TSC receiving treatment on an outpatient basis. Their medical records and test results were retrospectively examined. Results: At the time of TAND administration, 35 (64.8%) of the participants had focal epilepsy, three (5.6%) had generalized epilepsy, six (11.1%) had infantile spasms, and seven (13.0%) had Lennox-Gastaut syndrome. The most frequently reported behavioral problem was difficulty getting on with other people of similar age (38/58, 65.5%). Twenty patients had received previous diagnoses of psychiatric disorders, six of whom had received two or more concurrent diagnoses. A further evaluation after testing with the TAND checklist identified new psychiatric disorders in two patients. Among the 35 children who underwent a formal evaluation of intelligence, 27 (77.1%) exhibited intellectual disability. Of the school-aged patients, 65.6% (21/32) experienced difficulties with mathematics and 56.3% (18/32) with spelling. Difficulty dual-/multi-tasking (27/58, 46.6%) and low self-esteem (18, 31.0%) were the most frequent neuropsychological and psychosocial issues, respectively. Conclusion: Our findings indicate that patients with TSC tend to experience neurocognitive and socioemotional difficulties, and regular screening for TAND using the TAND checklist can be helpful for managing children with TSC in the clinical setting.
Trends in Pediatric Meningitis in South Korea during 2009 to 2017: Analysis of the Health Insurance Review and Assessment Service Database
Trends in Pediatric Meningitis in South Korea during 2009 to 2017: Analysis of the Health Insurance Review and Assessment Service Database
Jin Woo Kim;Soo Ahn Chae;Su Yeong Kim;Na Mi Lee;Dae Yong Yi;Sin Weon Yun;In Seok Lim
대한소아신경학회 / Annals of Child Neurology 제29권 제1호 / 2021 / 30-36 (7 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: Previous estimates of the cause- and age-specific frequency of pediatric meningitis in Korea were mainly derived from single- and multi-center studies. Herein, we used data on the number of cases of bacterial and viral meningitis from the Health Insurance Review and Assessment Service database to examine time- and sex-related trends. Methods: We extracted data on meningitis diagnoses registered in the Health Insurance Review and Assessment Service from 2009 to 2017, using Korean Standard Classification of Disease and Cause of Death codes. Information on 202,254 children aged 0 to 18 years was extracted. Detailed demographic and disease information was available for 84,543 children who underwent hospitalization. Results: Among all hospitalized patients, 2166, 36,155, and 46,192 children were diagnosed with bacterial, viral, or other types of meningitis, respectively. There were 30 cases of fungal meningitis and another 30 cases of meningitis attributable to other pathogens. The number of cases of bacterial and viral meningitis was highest among infants (1,087 [50.2%]) and patients in their early childhood (12,949 [35.9%]), respectively. Meningitis outbreaks were most likely to occur during the summer, and boys were more susceptible to meningitis than girls. The following pathogens most commonly caused infant meningitis: group B Streptococcus, Escherichia coli, and type B Haemophilus influenzae. Conclusion: This study reports the number of pediatric meningitis cases, stratified by age, disease type, and month/year. The present findings contribute to a better understanding of pediatric meningitis in Korea and provide a foundation for future research to identify the risk factors for this disease.
Precision Medicine Based on High-Throughput Nucleotide Sequencing for a Patient with SCN2A-Related Developmental Epileptic Encephalopathy
Precision Medicine Based on High-Throughput Nucleotide Sequencing for a Patient with SCN2A-Related Developmental Epileptic Encephalopathy
Se Eun Park;Dajeong Lee;Joo Young Song;Jeehun Lee;Jiwon Lee
대한소아신경학회 / Annals of Child Neurology 제29권 제1호 / 2021 / 43-46 (4 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Effects of Salbutamol in Collagen like Tail Subunit of Asymmetric Acetylcholinesterase-Related Congenital Myasthenic Syndrome: A First Korean Case
Effects of Salbutamol in Collagen like Tail Subunit of Asymmetric Acetylcholinesterase-Related Congenital Myasthenic Syndrome: A First Korean Case
Han Geul Kim;Jin Sung Lee;Kyung Won Kim;Hoon-Chul Kang;Se Hee Kim
대한소아신경학회 / Annals of Child Neurology 제29권 제1호 / 2021 / 54-56 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Recurrence of Epilepsy and Related Risk Factors after the Discontinuation of Antiepileptic Drugs in Children: A 10-Year Single-Center Study
Recurrence of Epilepsy and Related Risk Factors after the Discontinuation of Antiepileptic Drugs in Children: A 10-Year Single-Center Study
Jong Hoon Choi;Sun Jun Kim
대한소아신경학회 / Annals of Child Neurology 제29권 제1호 / 2021 / 22-29 (8 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: The criteria for discontinuing antiepileptic drugs (AEDs) in children with well-controlled epilepsy remain unclear. This study sought to identify the recurrence rate of epilepsy after the discontinuation of AEDs and the risk factors associated with recurrence. Methods: We retrospectively reviewed the records of 441 children who discontinued AEDs at our department of pediatrics from August 2007 to July 2017. AED tapering was performed in patients who were seizure-free for more than 2 years after taking AEDs, and patients were monitored for 1 year after the discontinuation of AEDs. Results: We found that 87 patients (87/441, 19.7%) experienced seizure recurrence within 1 year after the discontinuation of AEDs. Among them, 38 patients (38/87, 43.7%) experienced recurrence during AED tapering. The recurrence of seizures was related to the patient’s age at AED onset and when seizures were controlled, a history of seizure recurrence after previous discontinuation of AEDs or a seizure episode during AED administration, and no improvement of electroencephalographic (EEG) findings. Conclusion: The recurrence rate within 1 year after the discontinuation of AEDs was almost 20%, and nearly half of the recurrences took place during the tapering period. We recommend caution when considering whether to discontinue AEDs in patients with a history of seizure recurrence after AED discontinuation, a seizure episode during AED administration, or no (or slight) improvement of EEG findings.
Mirror Movements in a Pediatric Patient with a Basal Ganglia Germinoma
Mirror Movements in a Pediatric Patient with a Basal Ganglia Germinoma
Hoyeon Cheo;Seul Kee Kim;Kyung-Hwa Lee;Hee Jo Baek;Young Ok Kim
대한소아신경학회 / Annals of Child Neurology 제29권 제1호 / 2021 / 40-42 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
Clinical Characteristics of Epilepsy and Its Risk Factors in Neurofibromatosis Type 1: A Single-Center Study
Clinical Characteristics of Epilepsy and Its Risk Factors in Neurofibromatosis Type 1: A Single-Center Study
Areum Shin;Jun Chul Byun;Su-Kyeong Hwang;Soonhak Kwon;Yun Jeong Lee
대한소아신경학회 / Annals of Child Neurology 제29권 제1호 / 2021 / 1-7 (7 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학
초록보기
Purpose: This study investigated the clinical characteristics and risk factors of epilepsy in patients with neurofibromatosis type 1 (NF1) at a tertiary center. Methods: The medical records of 103 children diagnosed with NF1 from February 2009 to July 2019 were retrospectively reviewed. Demographic features, NF1-related features, seizure characteristics, treatment outcomes, and electroencephalography and brain magnetic resonance imaging (MRI) findings were compared between patients with and without epilepsy. Results: Among the 103 patients (median age, 11.5 years; age range, 1.0 to 34.8), 14 (13.6%) had epilepsy. The median age of seizure onset was 5.8 years (range, 1.1 to 18.9). Focal and generalized seizures were observed in nine (64.3%) and six (42.9%) patients, respectively. Five patients (35.7%) had a history of status epilepticus and one of them died of it. Two patients (14.3%) had drug-resistant epilepsy. On brain MRI obtained at the time of seizure onset, seven (50%) patients had unidentified bright objects and three (21.4%) had other structural abnormalities. Learning disability (odds ratio [OR], 4.5; 95% confidence interval [CI], 1.17 to 17.5) and a family history of epilepsy (OR, 39.7; 95% CI, 3.78 to 416.53), but not structural abnormalities, were significant risk factors for epilepsy. Conclusion: Epilepsy was more common in NF1 patients than in the general population. NF1 patients with epilepsy had various seizure types, but exhibited relatively good outcomes. The types of brain abnormalities were not significantly different between patients with and without epilepsy. Our results suggest that mechanisms other than structural brain abnormalities should be considered epileptogenic in NF1 patients.
Acute Necrotizing Encephalopathy Secondary to Mycoplasma pneumoniae Infection in a 4-Year-Old Boy
Acute Necrotizing Encephalopathy Secondary to Mycoplasma pneumoniae Infection in a 4-Year-Old Boy
Sang Hyun Park;Saelin Oh;Baik-Lin Eun;Jung Hye Byeon
대한소아신경학회 / Annals of Child Neurology 제29권 제1호 / 2021 / 51-53 (3 pages)
의약학>소아과학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 소아과학