영어 초록
Functional dyspepsia (FD) is defined as the presence of one or more of the following symptoms, postprandial fullness, early satiation, epigastric pain or burning sensation, with no evidence of structural disease to explain the symptoms. The prevalence of FD ranges from 5 to 11 percent worldwide. The pathophysiology of FD is not well elucidated and the management of patients with FD is still controversial, so the current treatment can improve the symptoms in only a small proportion of patients. In addition, the role of Helicobacter pylori (H. pylori) infection in FD has been emphasized. Although the mechanism remains uncertain, eradication of H. pylori is associated with a small but significant benefit in alleviating symptoms. The standard treatment of H. pylori is multiple antibiotics therapy. Its cure rate is up to 70 to 80%. But adverse drug effects such as nausea, epigastric pain, indigestion and diarrhea are reported about 50% of patients, and the drug discontinuation rate is also reported up to 10%. However, alternative treatment options have not been established yet. Therefore, the authors will review the functional medicine approach and nutritional therapy of FD and H. pylori infection, and suggest future research directions.