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홈 > 대한약학회 > 추계총회 및 학술대회
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Neuroprotective effects of baicalein, baicalin, and wogonin in primary cuItured rat cortical cells

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The versatile conversion of lactam to the a-alkylated amines via cyclic N,O-acetal TMS ether
Synthesis of lndeno[1.2-c]indenoisoquinoline Derivatives as Potential Topoisomerase Inhibitors
Design and Synthesis of Apio Nucleosides with Exocyclic Methylene Substituent
Solution-Phase Synthesis of a Library of Biaryl Amides Using Girard's reagent T as an Acid Chloride Scavenger
Regio- & Stereoselective Synthetic Method for Polyhydroxyamines using Chlorosulfonyl Isocyanate
Regioselective Substitution of 6,7-Dichloroquinoline-5,8-dione: Synthesis, Cytotoxicity, and X-ray crystal stucture of 4a, 10,11-Triazabenzo[3,2-a]fluorene-5,6-diones
Efficient Solid Phase Library Synthesis of 7-Alkoxy-1,3,4,5-tetrahydro-benzo [e][1,4] diazepin-2-one
Synthesis and hypoglycemic Activity of the Substituted Pyrrolidine Thiazolidinedione Derivatives
Synthesis of selective COX-2 inhibitors:Novel 1,5-diarylhydantoins via cyciization of methyl α-aminoacetates with aralkyl isocyanate
5~Arylidene-2(5H)-furanone Derivatives: Synthesis and Structure-Activity Relationship toward Cytotoxicity
Synthesis of Novel 3-Aminohydantoinyl-1,2-benzothiazine Derivatives for the COX-2 inhibitors
Synthesis of Azaisoflavones and Evaluation of Their Inhibitory Effects on lL–5
Revisit to Unfulfilled Premise of Arylsulfonylimidazolidinones as Anticancer Agent
Synthesis of 2,6-Diaromatic Substituted Pyridine Derivatives and Their Antitumor Activities
Stereoselective synthesis of novel 4'α-C-methyl branched novel carbocyclic nucleosides
Diastereoselective Synthesis of (+)-Frontalin
Lead Discovery and Optimization towards FXR Specific Compounds
The first synthesis of 4'α-C aryl branched carbocyclic nucleosides
Synthesis and Characterization of Polyamines and Their Metal Complexes
Design and Synthesis of Benzoquinoxalinediones
Diasteroselective synthesis of long chained keto amino acids derivatives
Design, Synthesis and Antitumor Evaluation of Terpyridine Derivatives Containing Pyridines at 4'-Position
Synthesis and Antiinflammatory Activity of 1,5- and 4,5-Disubstituted Imidazoles
Synthesis and Biological Studies of A Novel Series of Catechol Ether Type Derivatives as Potential Phosphodiesterase(PDE) Ⅳ Inhibitors
Synthesis of 3-arylisoquinolinamines and 3D-Quantitative Structure Activity Relationships Study
(-)-β-Narcotine:A Facile Synthesis and the Degradation with Ethyl Chloroformate
Acyclic Vanilloid Receptor Antagonist Based on Capsazepine
Cleavage of Benzyl and p-Methoxybenzyl Ethers Using Chlorosulfonyl Isocyanate Reaction
Diaralkylthiourea Derivatives as a Novel Vanilloid Receptor Antagonist
The Versatile Conversion of Acyclic Amides to a-Alkylated Amines
Antifungal activities of 2-arylthio-,2-arylthio-5-methoxy-,2,3-bisarylthio-juglones and 2,3-bisaryIthio-5,8-dimethoxy-1,4-naphthoquinones
Synthesis of Selenoflavonoid and Selenoisoflavonoid
Synthesis of Benzoquinoxalines
Design and Synthesis of Chromenone derivatives as Potential Antioxidants
Synthesis and Antifungal Activities of 2,5-Disubstituted-6-Arylamino-4,7-benzimidazolediones
Synthesis and evaluation of antifungal activities of 5-arylamino-6-chloro-4,7-dioxoindazoles
Synthesis of N-arylalkylbenzimidazolones(thiones) and 3-arylalkyl-3.4-dihydro-1H-quinazolinones (thinones) as conformatonally restricted PETT analogs for inhibition of HIV-1 reverse transcriptase
Straightforward synthesis of 4'α-C-hydroxymethyl branched novel carbocyclic nucleosides
3,4-Diaryl-2(5H)-Furanone Derivatives: Synthesis, Cytotoxicity, and Antitumor Activity
Structural Requirement of Isoflavonones for the Inhibitory Activity of Interleukin-5
Design, Synthesis and Biological Activities of Novel Vanilloid Receptor (VR) Agonists and Antagonists
Synthetic Approaches to Benzophenanthridines
EFFECTS OF ISOTHIAZOLE AND ISOXAZOLE DERIVATIVES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS
Synthesis of Novel Dimethylcyclopropyl Nucleosides as Potential Antiviral Agents
CoMFA of 1-phenyl-2-substituted thioureas for their cytotoxicity
Molecular Dynamics Simulation of Enantioselectivity in Metoprolol in complex
The 3-D QSAR study of antitumor arylsulfonylimidazolidinone derivatives by CoMFA and COMSIA
Synthesis and in vitro/in vivo properties of prednisolone 21-sulfate sodium as a colon-specific prodrug of prednisolone
Cytotoxic activity of 1-phenyl-2-substituted thiourea derivatives
In vitro Antitumor Activity and Nephrotoxicity of Pt(ll) Complexes Containing Diaminocyclohexane
Selective Cytotoxicity of Novel Platinum(ll) Complexes on Gastric Cancer Cell-Lines and Normal Kidney Cells
Anti-angiogenic and anti-tumor activity of 2'-hydroxy-4'-methoxychalcone
Ligand-Based Virtual Screening for inhibitors of PTP-1B with Antihyperglycemic properties
Stereocontrolled asymmetricsynthesis of pancratistatin
Total synthesis of Antofine by using Intramolecular 1,3-dipolar cycloaddition of Azidealkene
An Asymmetric Synthesis of (+)-Polyoxamic acid
Synthetic study of costunolide
Chiral Synthesis of Costunolide
Synthesis and Biological Evaluation of Pyrimidine Nucleosides Fused with 3',4'-Tetrahydrofuran Ring
Synthesis of 5-Azacytidine Nucleosides With Rigid Sugar Moiety As Potential Antitumor Agents
DESIGN AND SYNTHESIS OF A3 ADENOSINE RECEPTOR LIGANDS. 3'-FLUORO ANALOGUES OF Cl-IB-MECA
Asymmetric Synthesis of 12(S)-HETE
DESIGN AND SYNTHESIS OF A3 ADENOSINE RECEPTOR LIGANDS. 2'-FLUORO ANALOGUES OF Cl-IB-MECA
SYNTHESIS OF HALOGENATED 9-(DIHYDROXYCYCLOPENT-4'-ENYL) ADENINES AND THEIR INHIBITORY ACTIVITIES AGAINST S-ADENOSYLHOMOCYSTEINE HYDROLASE
A convenient synthesis of 2' or 3'-amino-2'(or 3')-deoxyadenosine and 5'-chloro-2' (or 3')-amino-deoxyadenosine analogues
Culture of rabbit chondrocytes on the HA-agarose scaffold for artificial cartilage
SYNTHESIS OF [1-FLUORO-2,2-BIS-(HYDROXYMETHYL) CYCLOPROPYLMETHYL] PURINESAS ANTIVIRAL AGENTS
Relationship Between Flavonoid Structure and Inhibition of Farnesyl Protein Transferase
Discrimination of Cnidium Rhizome using PCR-mediated RFLP
Ginsenosides Content of The Manufactured Ginseng Radices Extracts
On the Contents of Alkaloids in the Cho O by Processing Methods
Five compounds from leaves of Hovenia dulcis T
Three Cytotoxic compounds isolated from the seeds of Pharbitis nil
Additional Sesquiterpene Lactones from Ixeris sonchifolia
Biological Activities and Constituents of the Semen of Rumex crispus
A new 4-hydroxy-dodec-2E-enedioic acid from the stem bark of Albizzia julibrissin
Isolation and Structure Determination of Cytotoxic Compounds with Topoisomerse I and II Inhibitory Activity from the spikes of Prunella vulgaris var. lilacina
Comparison of Ginsenosides Composition in Various Panax Ginseng Roots Cultivated in Different Places and Years
Quantitative Analysis of 6-gingerol in the Zingiberis Rhizoma by Processing Methods
Three New Diarylheptanoids from the Roots of Jugfans mandshurica
In vivo Antinociceptive and Anti-inflammatory Effect of the Two Triterpenes, Ursolic Acid and 23-Hydroxyursolic Acid, of Cussonia bancoensis
Antimicrobial effects of ocotillone isolated from the stem bark of Ailanthus altisshima
Structure-Activity Relationship of Oleanane Disaccharides isolated from Akebia quinata on Both Cytotoxicity against Cancer Cells and NO inhibition against LPS-induced Macrophage 264.7
Anti-complement Activity of Flavonoids from Litsea japonica
A novel triterpene saponin from the roots of Platycodon grandoflorum
Terpenoids from Artemisia rubripes Nakai
Cytotoxic Constituents from Amanita pantherina(DC.ex Fr.) Krombh
Prostane-type Triterpenes from Alismatis Rhizoma and Their Anti-complement Activity
Phenolic Compounds from Barks of Pinus densiflora siebold et Zuccarini and Their NO Production Inhibitory Activities
Phytochemical Constitutents of Siegesbeckia pubesence Makino
Phytochemical constituents from Cacalia koraiensis Nakai
Chemical constituents of Synurus deltoides (Aiton) Nakai
Butyrylcholineesterase(BChE) Inhibitors froma Brown Alga Sargassum sp.
Diacylglycerol Acyltransferase Inhibitors from the Fruits of Evodia rutaecarpa and the Root of Salvia miltiorrhiza
Phenolic Compounds from Barks of Ulmus macrocarpa and Their Antioxidative Activities
Molecular cloning of a cytochrome P450-dependent monooxygenase cDNA from Panax ginseng C.A. Meyer
A Specific butyrylcholinesterase inhibitor from the fruits of Evodia officinalis
Antioxidant compounds from the twig of the Morus alba L.
Inhibition of HIV-1 Protease by isoflavonoids from Erythrina senegalensis
Xanthorrhizol inhibits pro-inflammatory mediators in mouse macrophage cells
Antioxidative activity of compounds from cuItivated Phellinus linteus
In vitro antioxidant triterpenoids from Prunus serrulata var. spontanea
Screening of Compounds Isolated from the Roots of Juglans mandshurica for DNA Topoisomerases I and Il Inhibitory Activity
Neuroprotective effect of extract of Angelica tenuissimae on ischemic damage after oxygen and glucose deprivation(OGD) in rat organotypic hippocampal slice
Anti-lipid peroxidative effect of Polygoni Radix
Isolation of the ppar-y ligands from the stem of the Zanthoxylum Schinifolium and their structure activity relationships
Study on the inhibition of Whole Blood Plateiet-Aggregation and antioxidative effects from Rhus verniciflua Stokes
Cytotoxicity and Antimutagenic Activity of the Thorns of Gleditsia sinensis Lam
Free Radical Scavenging Compounds of Polygoni Multiflori Ramulus
Free radical scavenging phenolic compounds of the leaves of Juglans sinensis
Screening of monocyte chemoattractant protein-1-induced chemotaxis inhibitors from medicinal herbs
Tyrosinase and melanin biosynthesis inhibitory activities of crude drugs
Inhibitory Effects of Natural Plant extracts on ICAM-1/LFA-1Mediated Adhesion of HL-60 Cells
An Isocoumarin with Hepatoprotective Activity in Hep G2 and Primary Hepatocytes from Agrimonia pilosa
INHIBITORY ACTION OF PROCESSED HERBAL MEDICINES ON THE PRODUCTION OF ADVANCED GLYCATION ENDPRODUCTS(AGEs)
Tyrosinase Inhibiting and DPPH Radical Scavenging Activities of Rosmarinic Acid and Its Methyl ester from Salvia miltiorrhiza
Study on antifungal activity of herb oils against Trichophyton spp
In vitro Antiinflammatory Activity of the Essential oil Extracted from Chrysanthemum sibiricum in Murine Macrophage RAW 264.7 Cells
Antigastritic and anti-ulcerative constituent from Panax ginseng head and its pharmacological activity
The effect of Cordyceps pruinosa on renal failure rats
The effect of Corni Fructus on renal function
Synergistic effect of a mixed herbal extract on bone loss in ovariectomized (OVX) rats
Alcohol Absorption Inhibitory Activity of Combination Extract from Several Medicinal Plants
Effect of Tectorigenin obtained from Pueraria thunbergiana Flowers on Phase I and-II Enzymes and Tissue Factor in the Streptozotocin-induced Diabetic Rat
Astragali Radix extract as a therapeutics on osteoporosis
Analgesic Effect of the Essential Oil from the Rhizomes of Cnidium officinale
Antinocicepetive effects of 3,4-Dicaffeoyl Quinic Acid of Ligularia fischeri var. spiciformis, caffeic acid and its methyl ester
Two new acylated neoline derivatives from Aconiti Tuber
Anti-Oxidative compounds from Quercus salicina bark
Developement of Quantitative Extraction Method of Amygdalin without Enzymatic Hydrolysis from Kyonin(Armeniacae Semen) by High Performance Liquid Chromatography
Simultaneous Determination of Curcumin and Glycyrrhizin Contents by High-performance Liquid Chromatography in Two Different Oriental Herbal Preparations of Kamijadowhan
Developement of Quantitative Extraction Method of Amygdalin without Enzymatic Hydrolysis from Tonin(Persicae Semen) by High Performance Liquid Chromatography
Studies on the constituents of the aerial part of Gastrodia elata Blume
New tsaokoin isomer with antifungal activity from the plant Amomum tsao-ko
Isolation of inhibitors of NF-κB activation by UV stimuli in transfectant HaCaT cells from Acanthopanacis sessilifflorum
Triterpene Components from the Leaves of Acanthopanax sessiliflorus
Regulation of the absorption of dietary sugar by α-glucosidase inhibitors from herbal medicines
Effect of Ethyl Acetate Extract from Caesalpinia sappan L. on Melanogenesis in Melan-a cells
Inhibitory effects of the medicinal plant extract on tyrosinase and elastase, and free radical scavenging effects
Cytotoxic and antimicrobial deterpene from Anisotome lyallii
The effects of natural medicinal herb extracts on a lipoprotein lipase activity
Effect of P-020701 on gastric lesion and ulcer in rats
Anxiolytic effect of Albizzia julibrissin using elevated plus-maze in rats
Purification and Chracterization of fibrinolytic enzymes from Vegetable warms
심혈관계 질환 치료제 후보물질 발굴을 위한 Soluble Epoxide Hydrolase 억제평가 방법 개발
Quantitative determination of pseudoephedrine in human plasma by reversed-phase liquid chromatography-electrospray ionization mass spectrometry
Concentrations of Dextromethorphan in Urine and Blood of Two Crime Suspects
Development of economic preparative method of (S)-(+)-enantiomer of arylpropionic acids
Simultaneous determination of corticosteroids in a herbal medicinal preparation by GC-MS
Assay Validation of Lansoprazole in Human Plasma
Studies on the Analysis of Anti-impotent Drugs (Ⅱ) - Rapid analysis of Sildenafil and modified Sildenafils using HPTLC
Proficiency Test for Pharmaceutical Companies in Analyzing Drug Products (Ⅱ) - Analysis of Variance of Factors Influencing Test Results
Chiral Separation of Non-Steroidal Inflammatory Drugs and Metabolites by Achiral Gas Chromatography as O-Trifluoroacetylated (-)-Menthyl Esters
Determination of Histamine in a Pharmaceutical Preparation after Clean-Up by Solid–Phase Extraction
Studies on the Analysis of Anti-impotent Drugs
Chiral separation of β-blockers after derivatization with a new chiral derivatization agent, GATC and Comparison with GITC on derivatizing conditions and chromatographic parameters
Narrowbore high-performance liquid chromatographic method for the determination of cetirizine in plasma using column switching
Proficiency Test for Pharmaceutical Companies in Analyzing Drug Products (I) - Comparison of Criteria for Satisfactory Test Results
Chiral discrimination studies of (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid by NMR spectroscopy
Chiral Separation of Aromatic Acids by Capillary Electrophoresis Using HP β-Cyclodextrin as the Chiral Selector
Dissolution Test for Indomethacin by the Portable Near-lnfrared(NIR) System
Enantiomeric Profiling Analysis of NSAIDs by Capillary Electrophoresis Using TM β-Cyclodextrin as the Chiral Selector
Qualification of various polymorphs by near-infrared(NIR) spectrophotometer
Development of a high-performance liquid chromatographic method for the determintion of levosulpiride in plasma
Potentiometric Characteristics of Metal(Ⅱ)-Triethylene tetramine-Acidic Drug Membrane Electrodes
Determination of triflusal in human plasma by high performance liquid chromatography with automated column switching system
Simultaneous quantitation of enalapril and enalaprilat in human plasma by high-throughput solid phase extraction and liquid chromatography/tandem mass spectrometry
Simultaneous determination of sildenafil and its active metabolite in human plasma using LC/MS/MS
Algorithm for finding the best regression models using NIR spectra
Chromatographic Analysis of Cilostazol in Human Plasma
Simultaneous determination of thirteen cosmetic preservatives in skin creams by HPLC-PDA method
Analysis of DA-6034, a New Flavonoid Derivative in Biological Fluids by Fluorescence Detector
Risk assessment of endocrine disruptors in cosmetics
Simultaneous determination of seven major human cytochrome P450 activities using LC/MS/MS
Studies on the evaluation of efficacy of functional cosmetics (l) - Studies on the in vitro SPF test method of sunscreen products
Comparison of CE and HPLC as analytical methods of (-)-yatein enantiomer from Cupressaceae plants
Determination of the water content in Citrus leaves by portable near in frared (NIR) system
Classification based on Near-IR spectra with application to Cnidium Rhizome
Anti-oxidant activities of the extracts from the herbs of Artemisia apiacea
Assay of Human Chorionic Gonadotropin in Urine of Athletes and Evaluation of Assay Kit Performance
Analysis of Branched PEG-Conjugated Interferon Alpha by Capillary Electrophoresis and MALDI-TOF Mass Spectrometry
Development of Immunostrip for DDT Detection
Chemiluminogenic imaging for highly sensitive detection of DNA
Optimization of a fiber optic probe for non-invasive blood glucose monitoring
Mucoadhesive Drug Carrier Using Poly(acrylic acid)/poly(vinyl alcohol) Interpolymer Complexes by Template Polymerization
Surfactant-free microspheres of poly(£-caprolactone)/poly(ethylene glycol)/poly(£-caprolactone) tribtock copolymers as a novel protein carriers
Preparation of polymeric nanoparticles from hydrophobically modified pullulan for hydrophobic drug carrier
New Formulation of Vitamin A Transdermal Therapeutic System
Preparation and Evaluation of Methacrylate copolymer Microspheres of Piroxicam
Solid Lipid Nanoparticles(SLN) as Controlled Release Subcutaneous Injections of Local Anesthetics
Ketoprofen-Polyethylene Glycol Conjugate:Pharmacokinetics, anti-inflammatory and analgesic activity
Enhanced Paclitaxel Bioavailability after Oral Administration of Paclitaxel Coadministered with Quercetin in Rats
lontophreotic delivery of vitamine-C-2-phosphate
THE RELATIONSHIP OF INTESTINAL ABSORPTION CLEARANCE AND PARTITION COEFFICIENT OF NINE BETA-BLOCKERS IN RATS
Preparation and release characteristics of PVP-based solid dispersion capsules containing solubilizers
Solubilization of poorly water-soluble drugs using solid dispersions
A study on the Physico-chemical Properties of CB-ph, s a New Anti-cancer drug
Pharmacokinetics of New Solubilizer in Intravenous Micelle Formulation of Paclitaxel in Mice
Tissue Distribution of Novel Polymeric Micellar Paclitaxel in Mice
DEVELOPMENT OF FAST-DISSOLVING TABLET(FDT) CONTAINING ONDANSETRON HYDROCHLORIDE (Onseran TM)
Standardization of uniformity of dosage unit for oral dosage forms
Transport of Organic Cations across Caco-2 Cell Monolayers
Effects of BuOH Extract of the Root of Aralia elata as an Absorption Enhancer on the Transport of Chondroitin Sulfate and Its Digestion Products In Vitro and In Vivo
Preparation and stability of N-terminal PEGylated Recombinant Human Epidermal Growth Factor
A Comparatives study for single-shot immunization of diphtheria toxoid with combined PLGA microspheres
Transfersomes-mediated gene transfer into organs in mice by direct application on intact skin
Growth inhibition of human pancreatic cancer cells by CR2945-targeted liposome
Characterization of the rhGHr eleased from rhGH-loaded PLGA microspheres
Effects of Sustained-Release Formulation of Recombinant Human Growth Hormone on Body weight, Bone growth and Organs in Hypophysectomized Rats
Preparation of mono-PEGylated interferon alpha-2a and its properties
A comparative study of pharmacopoeia between South Korea and North Korea(l)
Determination of enalapril in human blood by high-performance liquid chromatography mass spectrometer
The Effect of Nimodipine on the Pharmacokinetics of Cyclosporine in Rabbits
Does Agitation Condition Affect the Correlation Between in vitro Permeability of Xenobiotics across Caco-2 Cells and in vivo Bioavailability of the Compounds?
BIOEQUIVALENCE EVALUATION OF TIROPRAMIDE HCI 100 MG TABLETS IN HEALTHY MALE KOREAN VOLUNTEERS
HPLC Determination of Loratadine in Human Plasma with UV Detection and Pharmacokinetics of Loratadine Following Oral Administration of Tablet Formulation in Human
POPULATION PHARMACOKINETICS OF TERBINAFINE IN HEALTHY MALE KOREAN SUBJECTS USING NONMEM
Kinetic Characterization of Brain Distribution for KR-31378 in Rats
PK/PD modeling for cardiovascular effect of carvedilol in healthy volunteers
Pharmacokinetic Scaling of SJ-8029, a Novel Anticancer Agent Possessing Microtubule and Topoisomerase Inhibiting Activities, by Species-lnvariarit Time Methods
Kinetic Analysis of the Hepatic Uptake and Biliary Excretion of IH-901.,a Potential Anticancer Agents, in Rats
New Analytical Method of Cyclosporine A in Human Serum by High-performance Liquid Chromatography/Diode Array Detector and Its Application to Pharmacokinetics of Cyclosporine A in Human Volunteers
In vivo kinetics and biodistribution of a HIV-1 DNA vaccine after administration in mice
Pharmacokinetics of DA-3021 (mono-PEGylated recombinant human interferon α-2a) after Subcutaneous Administrations to Experimental Animals
In vivo Characterization of Sustained-Release Formulation of Recombinant Human Growth Hormone in Immunosuppressed Rats and Dogs
Effect of Polyethylenimine Type in Polylactic acid Nanoparticles/DNA Complex on the Transfection Efficiency
Thermo-sensitive lipid nanoparticles as a novel topical delivery system of retinol
In vitro and in vivo transfection efficiency of a cationic lipid containing sodium cholate
Polyethylene glycol (PEG)-modified cationic liposome mediated gene delivery
Nonviral Vector for Efficient Gene Transfer to Human Ovarian Adenocarcinoma Cells
Enhancement of Emulsion-mediated Gene Expression by Using Chitosan as a Pre-Condensing Agent
Cationic Emulsions with Galactosylaled Chitosan as a Novel Gene Delivery System
Enhanced p53 Gene Transfer to Human Ovarian Cancer Cells using Cationic Nonviral Vector, DDC
Clinical Effects of Gemcitabine and 5-Fluorouracil Combination therapy and Epirubicin, Cisplatin, and 5-Fluorouracil Combination therapy for patients with Pancreatic Cancer
The Effects of Oral Administrations of Panax ginseng and P. quinquefolium on Hemodynamics and Body Temperature in Healthy Young Men : Results of Single Blind Test
Evaluation of Yields by Mobilization and Harvesting of Peripheral Blood Stem Cells
Drug Use Evaluation of Hypoglycemic Agents in Type 2 Diabetes
Current Status of Medication Counseling Service at Community and Hospital Pharmacies in Korea Based on Nation-wide Survey Research in 2002
Prevention of Cardiovascular Events with Antiplatelet Agents in Diabetic Patients
Clinical Effects of Gemcitabine/5-FU Theraphy vs. Epirubicin/Cisplatin/5-FU in Pancreatic Cancer
Quality of Life in Pediatric Patients with Mucopolysaccharidosis
Cases of Adverse Drug Reaction Monitoring
Characterization of a zebrafish (Danio rerio) sphingosine 1-phosphate receptor expressed in the embryonic brain