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Purpose: Vasoproliferative tumor of the retina (VPTR) is a histologically benign lesion that can lead to visual loss due to associated complications. Herein, the authors report the clinical presentation, treatment, and prognosis of 3 VPTR cases. Case summary: Three eyes of 3 patients with VPTR were enrolled in the present study. The patients’ fundoscopic feature showed characteristic elevated lesions of the peripheral retina without previous history of ocular disease. The patients included 2 males and 1 female, with an average age of 44.7 years. Fluorescein angiography (FAG) and indocyanine green angiography (ICGA) were helpful in establishing the diagnosis of VPTR. Additionally, 1 patient underwent ultrasonography and 2 patients underwent magnetic resonance imaging (MRI). During the follow-up period, subtenon triamcinolone acetonide injection was performed for 1 patient with macular edema, and cryotherapy was performed for 1 patient with increased peripheral exudation. Conclusions: For an adequate diagnosis of VPTR, careful examination of the peripheral retina is important. In addition, FAG/ICGA and ultrasonography can be helpful in VPTR diagnosis. Furthermore, proper treatment according to each subset of complication during the follow-up period is recommended.

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