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Objective: There are several lines of evidence suggested that a serotonergic dysfunction is involved in the susceptibility to suicide. Recently, the T102C polymorphism of the serotonin 2A receptor gene has been suggested to be associated with suicide, but the results of genetic study are still controversial. The purpose of this study was to test whether the T102C polymorphism of the serotonin 2A receptor gene indicates susceptibility to suicidal behavior. Methods : The genotype and allele frequencies in the T102C polymorphism of the serotonin 2A receptor gene were studied by using TaqMan? assay to compare 80 Korean suicidal attempters with 125 Korean healthy controls. Results: The genotype and allele frequencies did not differ between suicidal attempters and control subjects. And, there were no significant associations between the genotypes and violence or non-violence. We also did not find the significant association between the allelic frequencies and violence or non-violence, Conclusion: These findings suggest that the T102C polymorphism in serotonin 2A receptor gene is unlikely to playa role in the genetic susceptibility to suicidal behavior, violence or non-violence in Korean suicidal patients. (Korean J Psychopharmacol 2005;16(1):69-75)

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