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홈 > 간행물 권호
  • 발행기관: 한방비만학회
  • 간행물:
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대한한방비만학회지(Journal of Korean Medicine for Obesity Research)

  • 발행기관 : 한방비만학회(The Society Korean Medicine for Obesity Research)
  • 출처구분 : 학회
  • 간행물유형 : 학술저널
  • 발행주기 : 연 2회간 (발행월:6,12)
  • Print ISSN : 1976-9334
  • Online ISSN : 2288-1522
  • 등재정보 : KCI 등재
대한한방비만학회지
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괴화, 어성초, 익모초에서 효소 분해에 의한 항산화 활성 변화 연구
괴화, 어성초, 익모초에서 효소 분해에 의한 항산화 활성 변화 연구
차배천(Bae Cheon Cha)
한방비만학회 / 한방비만학회지 제21권 1호 / 2021 / 1-9 (9 pages)
의약학>한의학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 한의학
초록보기
Objectives: The enzymatic hydrolysis is one of the processing methods that improve its effectiveness on medicinal herbs. In this research, changes in ingredients and activity by enzymatic hydrolysis were studied. Methods: For this study, a carbohydrate hydrolase such as viscozyme, which converts glycosides to aglycone, was applied to induce constituent changes in Sophora japonica Linne, Houttuynia cordata Thunberg and Leonurus japonicus Houttuyn. Changes in antioxidant activity were measured using the 1,1-diphenyl-2-picrylhydrazl (DPPH) method, and changes in ingredients were analyzed by high performance liquid chromatography. Results: As a result of enzymatic hydrolysis, the content of quercetin was increased from 1.26 mg/g to 29.66 mg/g in Sophora japonica Linne, from 0 mg/g to 0.66 mg/g in Houttuynia cordata Thunberg and from 0.43 mg/g to 0.71 mg/g in Leonurus japonicus Houttuyn. As a result of the antioxidant experimentation, the IC50 of Sophora japonica Linne decreased from 5 ug/ml (MeOH extract) and 9.1 ug/ml (EtOAc fraction) to 3.0 ug/ml, Houttuynia cordata Thunberg decreased from 15.6 ug/ml (MeOH extract) and 13.6 ug/ml (EtOAc fraction) to 11.2 ug/ml, and Leonurus japonicus Houttuyn decreased from 14.4 ug/ml (MeOH extract) and 12.6 ug/ml (EtOAc fraction) to 10.2 ug/ml. Conclusion: In conclusion, it was confirmed that glycoside rutin contained in the three medicinal herbs was changed to quercetin which is the aglycone, by the enzymatic hydrolysis using viscozyme. In terms of antioxidant activity, Sophora japonica Linne showed a significant antioxidant activity value that closes to the control group butylated hydroxyanisole. Houttuynia cordata Thunberg and Leonurus japonicus Houttuyn showed a minor increase in antioxidant activity.
산수유 추출물에 의한 LNCaP 전립선 세포의 증식 억제 및 양성 전립선 비대증 유발 인자의 발현에 미치는 영향
산수유 추출물에 의한 LNCaP 전립선 세포의 증식 억제 및 양성 전립선 비대증 유발 인자의 발현에 미치는 영향
김민영(Min Yeong Kim);지선영(Seon Yeong Ji);황보현(Hyun Hwangbo);이혜숙(Hyesook Lee);홍수현(Su Hyun Hong);최영현(Yung Hyun Choi)
한방비만학회 / 한방비만학회지 제21권 1호 / 2021 / 10-21 (12 pages)
의약학>한의학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 한의학
초록보기
Objectives: Benign prostatic hyperplasia (BPH) is a progressive pathological condition characterized by excessive proliferation of the prostate. In this study, we evaluated the effect of Corni Fructus water extract (CF) on the promotion of prostate cell proliferation by dihydrotestosterone (DHT). Methods: The effect of CF on the proliferation of LNCaP prostate cells was evaluated, and DHT was treated to induce an in vitro BPH model. To study the mechanism of inhibition of cell proliferation and BPH by CF, changes in the expression of key factors related to cell cycle and BPH were investigated. We further investigated the effect on the production of reactive oxygen species (ROS) and nitric oxide (NO) to evaluate the antioxidant and anti-inflammatory efficacy of CF. Results: Inhibition of LNCaP cell proliferation by CF was associated with decreased expression of cyclin D1 and cyclin A and increased expression of cyclin-dependent kinase inhibitor p21. CF also suppressed expression of BPH inducing factors such as 5α-reductase type 2 and androgen receptor (AR) as well as prostate specific antigen (PSA). Furthermore, CF significantly blocked DHT-induced LNCaP cell proliferation and effectively attenuated DHT-induced expression of BPH mediators and cyclins. In addition, CF inhibited DHT-induced oxidative and inflammatory reactions by inhibiting production of ROS and NO. Conclusion: Our results demonstrated that CF probably acted as 5α-reductase type 2 inhibitor, preventing the 5α-reductase type 2-AR signaling pathway, thereby reducing the conversion of testosterone to DHT and the expression of PSA, which is at least correlated with the antioxidant and anti-inflammatory activities of CF.
고도비만 환자 대상 한의 비만 상담을 포함한 한의치료의 체중 감량 효과
고도비만 환자 대상 한의 비만 상담을 포함한 한의치료의 체중 감량 효과
김성하(Sungha Kim);한경선(Kyungsun Han);권오진(Ojin Kwon);이원구(Wongu Lee);윤철상(Chulsang Yoon);이준환(Jun-Hwan Lee)
한방비만학회 / 한방비만학회지 제21권 1호 / 2021 / 22-31 (10 pages)
의약학>한의학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 한의학
초록보기
Objectives: We conducted a retrospective chart review to investigate the effects of Korean Medicine (KM) treatment on weight loss in patients with morbid obesity (body mass index [BMI]≥30 kg/m2) and to compare the effects of KM counseling and non-counseling on weight loss. Methods: We performed a retrospective chart review of patients with morbid obesity who received KM treatment for at least 1 month. We evaluated the effects of KM treatment on body weight, BMI, body fat, fat mass, EuroQol-5D, and the Korean version of the obesity-related quality of life scale (KOQOL). We also assessed the liver and kidney functions, and adverse events. We performed a comparative analysis between the counseling and non-counseling groups. Results: A total of 37 patients who underwent 4 weeks of KM treatment involving Wolbi-tang, electroacupuncture, and KM counseling were included in this study. Twenty-one patients were assigned to the counseling group and sixteen patients to the non-counseling group. There was a significant decrease in weight, BMI, fat mass, and KOQOL (P<0.05) with improvements in total cholesterol, low-density lipoprotein, and triglycerides. The counseling group had a greater reduction in body weight, BMI, body fat, and fat mass compared to the non-counseling group, although it was not significant. In the BMI below 35 (n=25), the reduction ratio of body weight, body fat mass, and body fat was higher in the counseling group than in the non-counseling group; additionally, body fat decreased significantly in counseling group (P<0.05). No severe adverse effects were observed. Conclusion: KM treatment could be effective for weight loss, especially in patients with morbid obesity, KM counseling could also be a good tool for weight loss, typically in patients with BMI<35 kg/m2.
체질량지수와 구강건강지표 사이의 상관성에 대한 연구
체질량지수와 구강건강지표 사이의 상관성에 대한 연구
심예윤(Hyeyoon Shim);박정환(Jeong Hwan Park);이상훈(Sanghun Lee);김호준(Hojun Kim)
한방비만학회 / 한방비만학회지 제21권 1호 / 2021 / 32-41 (10 pages)
의약학>한의학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 한의학
초록보기
Objectives: We aim to observe the relation of body mass index (BMI) and the indicators of oral health. Methods: 400 subjects participated in the study. The BMI values are calculated from the height and weight. For the tongue diagnosis, we used the tongue imaging device to analyze the color, tongue coating, and tooth marks. We measured the concentration of hydrogen sulfide (H2S) and methyl mercaptan (CH3SH) to evaluate the halitosis. The dry mouth was evaluated through the measurement of saliva secretion and with the questionnaire asking the frequency of dry mouth. Results: The BMI values were significantly higher in the group with light-white and blue-purple colored tongue, and significantly lower for lightly-coated tongue. However, the correlation of BMI and the amounts of saliva secretion was not significant as well as in the correlation of BMI and the concentration of H2S, CH3SH. In tongue diagnosis, the subjects who had blue-purple colored tongue also had significantly higher H2S and CH3SH, but tendency of lower saliva secretion. Conclusion: We obtain data showing that BMI value and the indicators of oral health including tongue diagnosis have meaningful correlation.
비만치료와 관련된 산삼복합약침요법에 대한 연구 동향 고찰
비만치료와 관련된 산삼복합약침요법에 대한 연구 동향 고찰
박정식(Jung-Sik Park)
한방비만학회 / 한방비만학회지 제21권 1호 / 2021 / 42-48 (7 pages)
의약학>한의학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 한의학
초록보기
Objectives: The purpose of this study was to review the studies of the wild ginseng complex pharmacopuncture related to obesity treatment. Methods: We searched the papers with key words of ‘wild ginseng complex pharmacopuncture’, ‘wild ginseng pharmacopuncture’, ‘obesity’, ‘fat’, ‘weight’ in Oriental medicine Advanced Searching Integrated System, KRpia, Koreanstudies Information Service System, Research Information Sharing Service, KoreaMed and PubMed, Scopus. We classified the papers by year, content and study type. Results: There were 7 studies about the wild ginseng pharmacopuncture related to obesity treatment. Cell studies were excluded because they were not related to obesity. Analysis of 3 animal experiments and 4 clinical studies were conducted to describe each research subject, method, and research results. Conclusion: More interest and further research will be needed on wild ginseng pharmacopuncture related to obesity treatment in the Korean medicine to achieve clinical application and to develop treatment protocols for the obesity disease.