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홈 > 간행물 권호
  • 발행기관: 대한구순구개열학회
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대한구순구개열학회지

  • 발행기관 : 대한구순구개열학회(Korean Cleft Lip And Palate Association)
  • 출처구분 : 학회
  • 간행물유형 : 학술저널
  • 발행주기 : 연 2회간 (발행월:6,12)
  • Print ISSN : 1229-0734
  • Online ISSN : 2586-2359
  • 등재정보 : KCI 등재후보
대한구순구개열학회지
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Association of RFC1 A80G Gene Polymorphism with Nonsyndromic Cleft Lip and Palate in Hispanics from Venezuela and Guatemala
Association of RFC1 A80G Gene Polymorphism with Nonsyndromic Cleft Lip and Palate in Hispanics from Venezuela and Guatemala
Jae-Sik Hur;Cory J Costanzo;Seung-Hak Baek;Miroslav Tolar;Mahsa Mortazavi;Marie M. Tolarova
대한구순구개열학회 / 대한구순구개열학회지 제24권 제1호 / 2021 / 1-9 (9 pages)
의약학>기타의약학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 치의학
초록보기
Objective: Investigate association of single nucleotide polymorphism rs1051266 on 80th nucleotide of reduced folate carrier 1 (RFC1) gene with non-syndromic cleft lip with or without cleft palate (nsCL±P). Materials and Methods: A case-control study design was used for this study. Samples of cases (188 individuals with nsCL±P) and controls (157 individuals) were Hispanics from Venezuela and Guatemala. Genomic DNA was extracted from blood spots on filter paper. RFC1-A80G genotypes were established using polymerase chain reaction and polyacrylamide gel electrophoresis. Results: Statistically significant higher proportion of mutated homozygotes GG and the lower homozygotes AA were found in cases compared to controls (p=.0234). Also, A and G allele frequencies were significantly different (p=.0088). When each location was evaluated separately the highly significant differences were observed only in Guatemalan but not in Venezuelan subsample. Conclusions: Our study showed that RFC1-A80G variant may contribute to the etiology of nsCL±P. It revealed differences in RFC1-A80G polymorphism frequencies in populations from different locations. A strong association of RFC1-A80G polymorphism with nsCL±P was observed in the population from Guatemala City, Guatemala only. We have shown that lumping together samples from different populations could hide differences in genotype and allele frequencies in individual populations.
선천성 안면기형을 동반한 증후군 환자의 악교정 수술
선천성 안면기형을 동반한 증후군 환자의 악교정 수술
윤민근(Min-Geun Yoon);김창수(Chang-Soo Kim);안재명(Jaemyung Ahn);팽준영(Jun-Young Paeng)
대한구순구개열학회 / 대한구순구개열학회지 제24권 제1호 / 2021 / 10-22 (13 pages)
의약학>기타의약학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 치의학
초록보기
There are various factors that have to be considered in orthognathic surgery for the syndromic patients with congenital facial deformities. The factors such as the shape of the jaws, pattern of mouth opening, masticatory muscle tension, degree of facial asymmetry, reconstruction of deformities and patient’s cooperation are required to be taken into consideration more than a routine treatment plan. For this reason, much more complex process, additional surgeries, and more precise and careful surgical planning are needed than general orthognathic surgery. Nearly all preparation procedures have been digitalized in recent orthognathic surgery cases. Computer-aided and 3D orthognathic surgery simulations allow for more precise model surgeries for syndromic patients with congenital facial deformities. The aim of this study is to examine the effective treatment method for syndromic patients with congenital facial deformities and discuss improvement of orthognathic surgery.
구개열 수술 후 구개열 아동의 음절성 옹알이 발달
구개열 수술 후 구개열 아동의 음절성 옹알이 발달
하승희(Seunghee Ha)
대한구순구개열학회 / 대한구순구개열학회지 제24권 제1호 / 2021 / 23-28 (6 pages)
의약학>기타의약학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 치의학
초록보기
Objectives: Canonical babbling (CB) is a major milestone in development of speech capacity in the first year and known as a significant predictor of later speech and language development. The purpose of this study was to examine canonical babbling development in children with cleft palate (CP) after cleft palate surgery compared to children without CP. Methods: Ten children with CP and 10 children without CP at 13-15 months of age participated in the study. Coders were analyzed twenty 5-minute segments with the highest child vocalization rate extracted from each child’s all-day home recording using Language ENvironment Analysis. Child vocalizations were determined based on syllable unit and each syllable was categorized as canonical and non-canonical syllables, syllables with glottal sounds, or syllables with glides. The number of each syllable type, canonical babbling ratios (CBR), and true canonical babbling ratio (TCBR) were compared between groups. Results: The results showed no significant group differences in total number of vocalization and syllables. Children with CP produced fewer canonical syllables than children without CP and the group differences in the CBR and TCBR were significant. Conclusion: This study suggests that children with CP show a limited development in canonical syllables even after cleft palate surgery and emphasizes the significance of followup services to monitor speech-language developmen for children with CP.
점막하 구개열 환자에서 비강점막의 절개 없이 시행한 연구개 내 근성형술: 증례보고
점막하 구개열 환자에서 비강점막의 절개 없이 시행한 연구개 내 근성형술: 증례보고
박정호(Jung Ho Park);김희열(Hee Youl Kim);백진아(Jin-A Baek)
대한구순구개열학회 / 대한구순구개열학회지 제24권 제1호 / 2021 / 29-33 (5 pages)
의약학>기타의약학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 치의학
초록보기
A submucous cleft palate (SMCP) results from a lack of normal fusion of the muscles within the soft palate. A SMCP is characterized by a bifid uvula, deficient midline muscle with zona pellucida, and osseous notch of the hard palate. When a submucous cleft is present, the muscles of the soft palate may not function properly which places a person at risk for speech problems (such as a hypernasality), middle ear disease, and swallowing difficulties. A SMCP requires surgery, if it causes problems. A velopharyngeal incompetence is a condition which a person cannot prevent air from escaping through the nose during the speech, and requires surgical repair of the palate. Intravelar veloplasty involves reconstruction of the abnormal soft palate muscles, tensor and levator veli palatine muscle. During the surgery, tensor and levator veli palatine muscles were separated from their abnormal attachment and from the oral and nasal mucosa. In this case report, we present a 48 months old child with SMCP who underwent intravelar veloplasty without separating the nasal mucosa.
편측성 구순구개열 환자의 교정적 정출술을 통한 치주조직 개선 치험례
편측성 구순구개열 환자의 교정적 정출술을 통한 치주조직 개선 치험례
서영수(Young-Soo Seo);박애현(Ae-Hyun Park);이경민(Kyung-Min Lee);조진형(Jin-Hyoung Cho);오민희(Min-Hee Oh)
대한구순구개열학회 / 대한구순구개열학회지 제24권 제1호 / 2021 / 34-41 (8 pages)
의약학>기타의약학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 치의학
초록보기
This case report describes a successful orthodontic treatment of a 26-year-old male patient with skeletal Class III and complete unilateral cleft lip and palate (CLP) on left side showed malformed microdontia on upper left lateral incisor and upper midline deviation to left side. To solve skeletal discrepancy, mandibular setback surgery and upper teeth extraction was performed. In order to easily correct the upper midline shifting, the 1st premolar was extracted on right side, while the lateral incisor was extracted on left side. In addition, to induce periodontal tissue regeneration, the left lateral incisor was extracted using forced eruption. After orthodontic treatment, the patient achieved improved facial profile and periodontal tissue on CLP area with favorable occlusion.
비인강 폐쇄 부전증 성인 환자에서 인두피판술 수술 후 객관적 언어평가: 증례보고
비인강 폐쇄 부전증 성인 환자에서 인두피판술 수술 후 객관적 언어평가: 증례보고
박종훈(Jong-Hoon Park);김다와(Da-Wa Kim);석현(Hyun Seok);백진아(Jin-A Baek);고승오(Seung-O Ko)
대한구순구개열학회 / 대한구순구개열학회지 제24권 제1호 / 2021 / 42-52 (11 pages)
의약학>기타의약학 / KDC : 기술과학 > 의학 / KCI : 의약학 > 치의학
초록보기
The purpose of this study is to objectively evaluate the post-surgical aerodynamic and acoustic characteristics of patients with velopharyngeal insufficiency (VPI) who received superiorly based pharyngeal flap surgery. Parameters for post-surgical evaluation of speech improvements vary by study designs, and the availability of objective research data is limited. VPI, also known as velopharyngeal Dysfunction (VPD), is a condition in which the soft palate and muscles of the posterior and lateral wall cannot form a velopharyngeal port. Objective evaluation of velopharyngeal closure is essential in the diagnosis and treatment of VPI. Hypernasality and limitations in speech articulation can be managed through various modalities, including speech therapy, speech-aid prosthetics, and surgical interventions. For patients with severe hypernasality, a superiorly based pharyngeal flap is the most commonly used procedure for the surgical correction of VPI. In this study, three patients (two male, one female) status post superiorly based pharyngeal flap surgery for hypernasality and inaccurate pronunciation were evaluated by a speech-language pathologist. Nasometers were used for objective measurement of post-surgical nasalance scores. The study results confirmed a significant and sustained improvement in nasality post superiorly based pharyngeal flap. Nasalance scores improved or reached normal limits during 1-2 months after surgical procedure, but with a tendency to relapse over time.