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홈 > 간행물 권호
  • 발행기관: 한국예방수의학회
  • 간행물:
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Journal of Preventive Veterinary Medicine(Journal of Preventive Veterinary Medicine)

  • 발행기관 : 한국예방수의학회(The Korean Society of Preventive Veterinary Medicine)
  • 출처구분 : 학회
  • 간행물유형 : 학술저널
  • 발행주기 : 계간 (발행월:3,6,9,12)
  • Print ISSN : 2287-7991
  • Online ISSN : 2287-8009
  • 등재정보 : KCI 등재
Journal of Preventive Veterinary Medicine
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Effect of functional foods containing lactic acid bacteria on DSS-induced colitis
Effect of functional foods containing lactic acid bacteria on DSS-induced colitis
Hyun-A Lee;Sunju So;Injeong Choi;Somi Kang;OKjin Kim
한국예방수의학회 / Journal of Preventive Veterinary Medicine Vol.45, No.3 / 2021 / 103-108 (6 pages)
의약학>의학일반 / KDC : 기술과학 > 의학 / KCI : 의약학 > 수의학
초록보기
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the colon and rectum with intervals of acute exacerbation. Its etiology remains unknown, although recent studies suggest that pro-inflammatory cytokines initiate the inflammatory responses. In this study, we investigated the ameliorative effects of YB-21 (new product containining Lactobacillus plantarum, Barley Bran and Nymphaeaceae) in a dextran sulfate sodium (DSS)-induced colitis in mice. The experimental groups were divided into 6 groups (n = 10) of ICR mice: normal control(NC), DSS-treated(PC, positive control), DSS+latic-L-treated (3×107CFU/ml), DSS+latic-M-treated (3×109CFU/ml), DSS+latic-H-treated (3×1011CFU/ml), and DSS+YB-21-treated. Histological examinations indicated that YB-21 suppressed edema, mucosal damage, and the loss of crypts induced by DSS. Moreover, YB-21 reduced serum level expressions of, tumor necrosis factor-α (TNF-α). These results suggest that YB-21 has an anti-colitic effect by the suppression of intestinal inflammatory responses in DSS-induced colitis in mice.
Effects of Peucedanum japonicum extracts on Helicobacter pylori infection
Effects of Peucedanum japonicum extracts on Helicobacter pylori infection
Hyung-Suk Lee;Okjin Kim
한국예방수의학회 / Journal of Preventive Veterinary Medicine Vol.45, No.3 / 2021 / 109-114 (6 pages)
의약학>의학일반 / KDC : 기술과학 > 의학 / KCI : 의약학 > 수의학
초록보기
Helicobacter (H.) pylori is one of the most common pathogenic bacteria in the human gut, and is also one of the most important factors that cause digestive disorders such as chronic inflammation, gastric ulcers, and even gastric cancer. Since the use of various antibiotics to treat H. pylori infection is associated with the development of resistance in this bacterium, the aim of this study was to determine the anti-H. pylori effects of Peucedanum japonicum extracts (PJE) in the stomach tissue of C57BL/6 mice. In this experimental study, 50 C57BL/6 mice in five groups were evaluated. After induction of H. pylori infection in mice with the standard strain of H. pylori (ATCC 43504), the infected mice were treated with 3 different doses of PJE in different groups. Then, the anti-H. pylori effects of PJE were evaluated by rapid urease test (CLO), histopathological exam and blood interleukin (IL)-8 ELISA analysis. Based on CLO results, H. pylori eradication effects of PJE was observed. H. pylori infection of C57BL/6 mice showed significant increase of histopathological lesion scores. However, the treatment of PJE showed significant decrease of histopathological lesion scores. The treatment of PJE decreased gastric inflammation and mucosal lesions in the stomach of H. pylori-infected mice. Blood IL-8 levels were elevated 4 weeks after H. pylori inoculation. However, the treatment of PJE showed significant decrease of IL-8 level. According to the results of this study, PJE could be useful in the reduction of H. pylori infection in the mouse model.
Hepatoprotective potential of Dendropanax morbifera leaf extracts on ethanol-induced liver toxicity in Sprague-Dawley rats
Hepatoprotective potential of Dendropanax morbifera leaf extracts on ethanol-induced liver toxicity in Sprague-Dawley rats
Yongjae Han;Dong-Eon Lee;Cheol-Hee Choi;Hu-Jang Lee
한국예방수의학회 / Journal of Preventive Veterinary Medicine Vol.45, No.3 / 2021 / 115-120 (6 pages)
의약학>의학일반 / KDC : 기술과학 > 의학 / KCI : 의약학 > 수의학
초록보기
This study investigated the preventive effect of Dendropanax morbifera leaf extracts (DMLEs) drew out with water, 30, 50 and 70% ethanol against alcohol-induced hepatotoxicity in vitro and vivo. The 3-(4,5-dimethylthiazol-2-yl)-2,5-dipenyltetrazolium bromide (MTT) assay was performed to assess cytotoxic activity of DMLEs, and the half-maximal inhibitory concentration (IC50) ranged between 1.11 and 2.08 mg/mL on Hep3B cells. In preventing ethanol-induced-hepatotoxicity on Hep3B cells, 30 and 50% ethanol DMLEs were significantly effective compared to the 5% ethanol treatment control. In addition, the 30% ethanol DMLE was orally provided to rats 30 min prior to the administration of ethanol (3 mL/kg body weight). At 1, 3 and 5 h after ethanol treatment, the plasma levels of ethanol and acetaldehyde were determined. The 30% ethanol DMLE effectively decreased the plasma ethanol levels during 5 h but increased the plasma acetaldehyde levels until 3 h and then significantly decreased at 5 h, as compared to the control. These results indicate that the 30% ethanol DMLE possesses a potent preventive effect against ethanol-induced liver toxicity in Sprague-Dawley rats.
The minimum zoo accreditation standards for Korean local zoos
The minimum zoo accreditation standards for Korean local zoos
Seung-Aee Ma;Chae-Yeon Lee;Jin Soo Han
한국예방수의학회 / Journal of Preventive Veterinary Medicine Vol.45, No.3 / 2021 / 121-128 (8 pages)
의약학>의학일반 / KDC : 기술과학 > 의학 / KCI : 의약학 > 수의학
초록보기
World-class zoos have been recognized proponents of both animal welfare and wildlife conservation. The Korean zoos are in controversy over its existence, citing poor role performance. As one of the efforts to protect animals’ welfare and enhance wildlife conservation, leading zoos have been accredited through the inspections and evaluations. To improve the quality of Korean zoos, an accreditation standard that fits for Korean environment needs to be set. Out of various zoo accreditation standards around the world, we compared each category of all five publicly available accreditation standards; the Association of Zoos and Aquariums in the United States(AZA), Canada s Accredited Zoos and Aquarium(CAZA), European Association of Zoos and Aquaria(EAZA), Zoological Association of America(ZAA), and the Pan-African Association of Zoos and Aquariums(PAAZA). Based on the analysis result, we established 10 essential categories that were finally approved by the Focus group interview; animal welfare and care and management, veterinary care, conservation, education and interpretation, governing authority, staff, finance, physical facilities, safety and security, and master & strategy plan. This minimum zoo accreditation standards would enlighten the path to improve animal welfare and wildlife conservation of Korean local zoos.
Effects of natural killer cell-derived exosomes in canine mammary tumor model
Effects of natural killer cell-derived exosomes in canine mammary tumor model
Se-A Lee;Na-Yeon Gu;So Yeon Jeong;Seong-In Lim;Jienny Lee;Yoon-Hee Lee;Bang-Hun Hyun
한국예방수의학회 / Journal of Preventive Veterinary Medicine Vol.45, No.3 / 2021 / 129-137 (9 pages)
의약학>의학일반 / KDC : 기술과학 > 의학 / KCI : 의약학 > 수의학
초록보기
Natural killer (NK) cells have cytotoxic effects on tumor cells and viral pathogens. NK cell-derived exosomes (NK-exosomes) also express typical NK cell markers and cytotoxic molecules, therefore, exert anti-tumor and immune homeostatic activities. In this study, canine NK-exosomes separated from cytotoxic NK cell supernatant carried specific markers such as CD81, Alix, and Perforin 1. We examined the anti-tumor effects of NK-exosomes in an experimental murine model using the canine mammary carcinoma cells, REM134. REM134 cells were xenografted of mammary fat pad of mice. CD133, Bmi-1, MMP-3, IL-6, TNF-α, and PCNA are useful as a molecular marker for tumorigenesis and metastasis. The treatment of canine NK-exosomes inhibited tumor growth and significantly (p<0.01) downregulated the expression of Bmi-1, MMP-3, IL-6, TNF-α, and PCNA in REM134-treated mice. Also, the expression of CD133, potent cancer stem cell marker, was significantly downregulated in the canine NK-exosomes-treated mice compared with that of the tumor group. Collectively, these results suggested that canine NK-exosomes has a potential capacity for regulation of cancer progression and metastasis against canine mammary carcinoma.
Effects of needleless intradermal injection of multivalent foot and mouth disease vaccine on granuloma formation at neck region in fattening pigs
Effects of needleless intradermal injection of multivalent foot and mouth disease vaccine on granuloma formation at neck region in fattening pigs
Chang-Won Im;Wan-Kyu Lee
한국예방수의학회 / Journal of Preventive Veterinary Medicine Vol.45, No.3 / 2021 / 138-143 (6 pages)
의약학>의학일반 / KDC : 기술과학 > 의학 / KCI : 의약학 > 수의학
초록보기
The abnormal meat could caused by abscess, fibrosis and granuloma in the region of the neck by the adverse effect of foot-and-mouth disease (FMD) vaccination practice for Korean swine. After FMD vaccination was implemented in 2010, the number of incidences of abnormal meat has been increasing. In this study, it was evaluated whether needless intradermal injection (NII) of FMD vaccine reduces abnormal meat at the injection site in comparison to conventional intramuscular injection (IM). In addition, the onset of humoral immunity was analyzed in order to see if NII of this vaccine is able to mount comparable antibody response with IM. This study was carried out in four Korean pig farms. The O-type FMD vaccine was implemented via NII at three farms and the control group was vaccinated via IM. Antibody titers were compared from the serum samples taken from 10 random pigs at age of 8, 12, 16 and 22~24 weeks of age. The O+A type FMD vaccine was also compared with the same protocol. When test animals were slaughtered, incidence, type and size of abnormal meat were recorded. The results of this study showed that the antibody titers between intradermal and intramuscular group were similar but a significant difference in the incidence of abnormal meat formation was observed between two groups (p < 0.05). In summary, needless intradermal injection of FMD vaccination was proven to be effective for the onset of humoral immunity and reducing abnormal meat formation.
Anti-hyperlipidemic effects of Dendropanax morbifera L. leaf water extract in hyperlipidemic rats fed a high-fat diet
Anti-hyperlipidemic effects of Dendropanax morbifera L. leaf water extract in hyperlipidemic rats fed a high-fat diet
Ye-Jin Kang;Min-Jae Kim;Jin-Hyeok Kim;Yongjae Han;Kwang-Il Park;Suk Kim;Hu-Jang Lee
한국예방수의학회 / Journal of Preventive Veterinary Medicine Vol.45, No.3 / 2021 / 144-149 (6 pages)
의약학>의학일반 / KDC : 기술과학 > 의학 / KCI : 의약학 > 수의학
초록보기
The present study is designed to investigate the hypolipidemic effect of the hot-water extract from the leaves of Dendropanax morbifera L. (DMWE) in hyperlipidemic rats. Thirty male 5-week-old rats were grouped as follows: Normal control (NC) given distilled water; hyperlipidemic control (HC) administered with distilled water; drug treatment (DT) orally administered with atorvastatin (10 mg/kg body weight (BW)); DMWE-treated groups (DM-50, DM-100 and DM-200) treated with DMWE 50, 100 and 200 mg/kg BW, respectively. All groups (except for NC) were fed a high-fat diet during the experiment. After 4 weeks of administration, the BW of all groups treated with DMWEs significantly increased compared to that of HC (p<0.05) and showed no significant difference compared to that of NC. In addition, serum total cholesterol levels in all groups treated with DMWEs were meaningfully decreased, compared to that in HC (p<0.05). In serum triglyceride (TG) and low-density lipoprotein-cholesterol levels, both DM-100 and DM-200 considerably decreased compared to HC (p<0.05), and no significant differences in TG levels were between DM-100 and DM-200. In high-density lipoprotein-cholesterol levels, DM-200 was statistically different compared to HC, and there were no significant differences between DM-100, DM-200 and DT. Furthermore, aspartate transaminase and alanine aminotransferase concentrations of DM-100 and DM-200 were significantly decreased compared to those of HC (p<0.05). From results portrayed above, DMWE at the concentration of 100 mg/kg BW has been identified to be effective in the treatment of hyperlipidemic rats.
Toxic trace elements in spraints of Eurasian otters (Lutra lutra) in the Daechung Lake area
Toxic trace elements in spraints of Eurasian otters (Lutra lutra) in the Daechung Lake area
Seungwoo Lee;Hye-Jin Yoo;Sung Yong Han;Doug-Young Ryu
한국예방수의학회 / Journal of Preventive Veterinary Medicine Vol.45, No.3 / 2021 / 150-152 (3 pages)
의약학>의학일반 / KDC : 기술과학 > 의학 / KCI : 의약학 > 수의학
초록보기
The concentrations of four potentially toxic elements were analyzed in 70 spraint samples of Eurasian otters from the Daechung Lake area. The median concentrations of As, Hg, Ni, and Pb were 1.19, 1.06, 9.95, and 0.37 μg/g dry weight, respectively. A moderate negative correlation was observed between the levels of Hg and Pb (rs = -0.47). The Hg levels showed a weak negative correlation with the distances of the sampling locations from the Daechung Dam (rs = -0.35). This study provides baseline information on the health risks associated with the hazardous elements in otter species.